8q1q
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8q1q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8q1q OCA], [https://pdbe.org/8q1q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8q1q RCSB], [https://www.ebi.ac.uk/pdbsum/8q1q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8q1q ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8q1q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8q1q OCA], [https://pdbe.org/8q1q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8q1q RCSB], [https://www.ebi.ac.uk/pdbsum/8q1q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8q1q ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | == Function == | ||
| - | [https://www.uniprot.org/uniprot/KEAP1_MOUSE KEAP1_MOUSE] Retains NFE2L2/NRF2 in the cytosol. Functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. Targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. May also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome (By similarity).<ref>PMID:9887101</ref> <ref>PMID:12682069</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Current revision
mouse Keap1 in complex with stapled peptide
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