8r0g
From Proteopedia
(Difference between revisions)
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==Capsid structure of Giardiavirus (GLV) CAT strain== | ==Capsid structure of Giardiavirus (GLV) CAT strain== | ||
| - | < | + | <SX load='8r0g' size='340' side='right' viewer='molstar' caption='[[8r0g]], [[Resolution|resolution]] 2.60Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[8r0g]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Giardia_lamblia_virus Giardia lamblia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8R0G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8R0G FirstGlance]. <br> | <table><tr><td colspan='2'>[[8r0g]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Giardia_lamblia_virus Giardia lamblia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8R0G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8R0G FirstGlance]. <br> | ||
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8r0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8r0g OCA], [https://pdbe.org/8r0g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8r0g RCSB], [https://www.ebi.ac.uk/pdbsum/8r0g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8r0g ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8r0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8r0g OCA], [https://pdbe.org/8r0g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8r0g RCSB], [https://www.ebi.ac.uk/pdbsum/8r0g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8r0g ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | == | + | <div style="background-color:#fffaf0;"> |
| - | + | == Publication Abstract from PubMed == | |
| + | The Giardia lamblia virus (GLV) is a non-enveloped icosahedral dsRNA and endosymbiont virus that infects the zoonotic protozoan parasite Giardia duodenalis (syn. G. lamblia, G. intestinalis), which is a pathogen of mammals, including humans. Elucidating the transmission mechanism of GLV is crucial for gaining an in-depth understanding of the virulence of the virus in G. duodenalis. GLV belongs to the family Totiviridae, which infects yeast and protozoa intracellularly; however, it also transmits extracellularly, similar to the phylogenetically, distantly related toti-like viruses that infect multicellular hosts. The GLV capsid structure is extensively involved in the longstanding discussion concerning extracellular transmission in Totiviridae and toti-like viruses. Hence, this study constructed the first high-resolution comparative atomic models of two GLV strains, namely GLV-HP and GLV-CAT, which showed different intracellular localization and virulence phenotypes, using cryogenic electron microscopy single-particle analysis. The atomic models of the GLV capsids presented swapped C-terminal extensions, extra surface loops, and a lack of cap-snatching pockets, similar to those of toti-like viruses. However, their open pores and absence of the extra crown protein resemble those of other yeast and protozoan Totiviridae viruses, demonstrating the essential structures for extracellular cell-to-cell transmission. The structural comparison between GLV-HP and GLV-CAT indicates the first evidence of critical structural motifs for the transmission and virulence of GLV in G. duodenalis. | ||
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| + | High-resolution comparative atomic structures of two Giardiavirus prototypes infecting G. duodenalis parasite.,Wang H, Marucci G, Munke A, Hassan MM, Lalle M, Okamoto K PLoS Pathog. 2024 Apr 10;20(4):e1012140. doi: 10.1371/journal.ppat.1012140. , eCollection 2024 Apr. PMID:38598600<ref>PMID:38598600</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 8r0g" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
| - | </ | + | </SX> |
[[Category: Giardia lamblia virus]] | [[Category: Giardia lamblia virus]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
Current revision
Capsid structure of Giardiavirus (GLV) CAT strain
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