8tv0
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8tv0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8tv0 OCA], [https://pdbe.org/8tv0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8tv0 RCSB], [https://www.ebi.ac.uk/pdbsum/8tv0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8tv0 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8tv0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8tv0 OCA], [https://pdbe.org/8tv0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8tv0 RCSB], [https://www.ebi.ac.uk/pdbsum/8tv0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8tv0 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
- | == | + | <div style="background-color:#fffaf0;"> |
- | + | == Publication Abstract from PubMed == | |
+ | The Toxin Complex (Tc) superfamily consists of toxin translocases that contribute to the targeting, delivery, and cytotoxicity of certain pathogenic Gram-negative bacteria. Membrane receptor targeting is driven by the A-subunit (TcA), which comprises IgG-like receptor binding domains (RBDs) at the surface. To better understand XptA2, an insect specific TcA secreted by the symbiont X. nematophilus from the intestine of entomopathogenic nematodes, we determined structures by X-ray crystallography and cryo-EM. Contrary to a previous report, XptA2 is pentameric. RBD-B exhibits an indentation from crystal packing that indicates loose association with the shell and a hotspot for possible receptor binding or a trigger for conformational dynamics. A two-fragment XptA2 lacking an intact linker achieved the folded pre-pore state like wild type (wt), revealing no requirement of the linker for protein folding. The linker is disordered in all structures, and we propose it plays a role in dynamics downstream of the initial pre-pore state. | ||
+ | |||
+ | Structures of the Insecticidal Toxin Complex Subunit XptA2 Highlight Roles for Flexible Domains.,Martin CL, Chester DW, Radka CD, Pan L, Yang Z, Hart RC, Binshtein EM, Wang Z, Nagy L, DeLucas LJ, Aller SG Int J Mol Sci. 2023 Aug 25;24(17):13221. doi: 10.3390/ijms241713221. PMID:37686027<ref>PMID:37686027</ref> | ||
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+ | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
+ | </div> | ||
+ | <div class="pdbe-citations 8tv0" style="background-color:#fffaf0;"></div> | ||
+ | == References == | ||
+ | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> |
Current revision
XptA2 wild type
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