8yd7
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8yd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8yd7 OCA], [https://pdbe.org/8yd7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8yd7 RCSB], [https://www.ebi.ac.uk/pdbsum/8yd7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8yd7 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8yd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8yd7 OCA], [https://pdbe.org/8yd7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8yd7 RCSB], [https://www.ebi.ac.uk/pdbsum/8yd7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8yd7 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | == Function == | ||
| - | [https://www.uniprot.org/uniprot/CFLAR_HUMAN CFLAR_HUMAN] Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.<ref>PMID:9880531</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Current revision
Structure of FADD/Caspase-8/cFLIP death effector domain assembly
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