8qtr

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'''Unreleased structure'''
 
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The entry 8qtr is ON HOLD until 2025-10-13
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==Cryo-EM structure of the FB-bound yeast Ceramide Synthase==
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<StructureSection load='8qtr' size='340' side='right'caption='[[8qtr]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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Authors: Schaefer, J., Clausmeyer, L., Koerner, C., Moeller, A., Froehlich, F.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8qtr]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8QTR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8QTR FirstGlance]. <br>
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Description: Cryo-EM structure of the FB-bound yeast Ceramide Synthase
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3PE:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE'>3PE</scene>, <scene name='pdbligand=7PO:hexacosanoic+acid'>7PO</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene>, <scene name='pdbligand=PIJ:[(2S)-1-hexadecanoyloxy-3-[hydroxy-[(2S,3R,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy-phosphoryl]oxy-propan-2-yl]+heptadecanoate'>PIJ</scene>, <scene name='pdbligand=WXE:(2~{R})-2-[2-[(5~{S},6~{S},7~{R},9~{S},11~{S},16~{S},18~{R},19~{S})-19-azanyl-6-[(3~{S})-3-carboxy-5-oxidanyl-5-oxidanylidene-pentanoyl]oxy-5,9-dimethyl-11,16,18-tris(oxidanyl)icosan-7-yl]oxy-2-oxidanylidene-ethyl]butanedioic+acid'>WXE</scene></td></tr>
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[[Category: Froehlich, F]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8qtr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8qtr OCA], [https://pdbe.org/8qtr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8qtr RCSB], [https://www.ebi.ac.uk/pdbsum/8qtr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8qtr ProSAT]</span></td></tr>
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[[Category: Koerner, C]]
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</table>
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[[Category: Schaefer, J]]
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== Function ==
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[[Category: Clausmeyer, L]]
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[https://www.uniprot.org/uniprot/LAG1_YEAST LAG1_YEAST] Component of the ceramide synthase complex that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward hexacosanoyl-CoA (C26:0-CoA) (PubMed:11694577, PubMed:12869556). N-acylates sphinganine and phytosphingosine bases to form dihydroceramides and phytoceramides, respectively (PubMed:12869556). Redundant with LAC1. Facilitates ER-to-Golgi transport of GPI-anchored proteins. Involved in the aging process. Deletion of LAG1 results in a pronounced increase (approximately 50%) in mean and in maximum life span.<ref>PMID:10198056</ref> <ref>PMID:11387200</ref> <ref>PMID:11694577</ref> <ref>PMID:12869556</ref> <ref>PMID:15236759</ref> <ref>PMID:15692566</ref>
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[[Category: Moeller, A]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Saccharomyces cerevisiae]]
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[[Category: Clausmeyer L]]
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[[Category: Froehlich F]]
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[[Category: Koerner C]]
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[[Category: Moeller A]]
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[[Category: Schaefer J]]

Revision as of 07:09, 23 October 2024

Cryo-EM structure of the FB-bound yeast Ceramide Synthase

PDB ID 8qtr

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