8xl2

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Current revision (07:12, 23 October 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8xl2 is ON HOLD until Paper Publication
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==Human acetyl-CoA carboxylase 1 filament in complex with acetyl-CoA (ACC1-inact)==
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<StructureSection load='8xl2' size='340' side='right'caption='[[8xl2]], [[Resolution|resolution]] 2.73&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8xl2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8XL2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8XL2 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.73&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8xl2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8xl2 OCA], [https://pdbe.org/8xl2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8xl2 RCSB], [https://www.ebi.ac.uk/pdbsum/8xl2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8xl2 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/ACACA_HUMAN ACACA_HUMAN] Defects in ACACA are a cause of acetyl-CoA carboxylase 1 deficiency (ACACAD) [MIM:[https://omim.org/entry/613933 613933]; also known as ACAC deficiency or ACC deficiency. An inborn error of de novo fatty acid synthesis associated with severe brain damage, persistent myopathy and poor growth.<ref>PMID:6114432</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/ACACA_HUMAN ACACA_HUMAN] Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.<ref>PMID:20952656</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Human acetyl-coenzyme A (CoA) carboxylases (ACCs) catalyze the carboxylation of acetyl-CoA, which is the rate-limiting step in fatty acid synthesis. The molecular mechanism underlying the dynamic organization of ACCs is largely unknown. Here, we determined the cryo-electron microscopy (EM) structure of human ACC1 in its inactive state, which forms a unique filament structure and is in complex with acetyl-CoA. We also determined the cryo-EM structure of human ACC1 activated by dephosphorylation and citrate treatment, at a resolution of 2.55 A. Notably, the covalently linked biotin binds to a site that is distant from the acetyl-CoA binding site when acetyl-CoA is absent, suggesting a potential coordination between biotin binding and acetyl-CoA binding. These findings provide insights into the structural dynamics and regulatory mechanisms of human ACCs.
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Authors: Zhou, F.Y., Zhang, Y.Y., Zhou, Q., Hu, Q.
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Filament structures unveil the dynamic organization of human acetyl-CoA carboxylase.,Zhou F, Zhang Y, Zhu Y, Zhou Q, Shi Y, Hu Q Sci Adv. 2024 Oct 11;10(41):eado4880. doi: 10.1126/sciadv.ado4880. Epub 2024 Oct , 9. PMID:39383219<ref>PMID:39383219</ref>
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Description: Human acetyl-CoA carboxylase 1 filament in complex with acetyl-CoA (ACC1-ACO)
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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[[Category: Hu, Q]]
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<div class="pdbe-citations 8xl2" style="background-color:#fffaf0;"></div>
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[[Category: Zhang, Y.Y]]
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== References ==
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[[Category: Zhou, Q]]
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<references/>
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[[Category: Zhou, F.Y]]
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Hu Q]]
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[[Category: Zhang YY]]
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[[Category: Zhou FY]]
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[[Category: Zhou Q]]

Current revision

Human acetyl-CoA carboxylase 1 filament in complex with acetyl-CoA (ACC1-inact)

PDB ID 8xl2

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OCA

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