9c3c

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Current revision (07:12, 23 October 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9c3c is ON HOLD until Paper Publication
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==Cryo-EM structure of native dystrophin-glycoprotein complex (DGC)==
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<StructureSection load='9c3c' size='340' side='right'caption='[[9c3c]], [[Resolution|resolution]] 4.30&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9c3c]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9C3C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9C3C FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.3&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9c3c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9c3c OCA], [https://pdbe.org/9c3c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9c3c RCSB], [https://www.ebi.ac.uk/pdbsum/9c3c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9c3c ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DAG1_RABIT DAG1_RABIT] The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization. Extracellular peripheral glycoprotein that acts as a receptor for extracellular matrix proteins containing laminin-G domains. Receptor for laminin-2 (LAMA2) and agrin in peripheral nerve Schwann cells (By similarity). Also acts as a receptor for laminin LAMA5 (By similarity).[UniProtKB:O18738] Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity (By similarity).
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Oryctolagus cuniculus]]
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[[Category: Liu S]]
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[[Category: Su T]]
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[[Category: Xia X]]
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[[Category: Zhou ZH]]

Current revision

Cryo-EM structure of native dystrophin-glycoprotein complex (DGC)

PDB ID 9c3c

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OCA

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