1tow

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1tow.gif|left|200px]]
[[Image:1tow.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1tow |SIZE=350|CAPTION= <scene name='initialview01'>1tow</scene>, resolution 2.00&Aring;
+
The line below this paragraph, containing "STRUCTURE_1tow", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=CRZ:4-(9H-CARBAZOL-9-YL)BUTANOIC+ACID'>CRZ</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1tow| PDB=1tow | SCENE= }}
-
|RELATEDENTRY=[[1tou|1TOU]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tow FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tow OCA], [http://www.ebi.ac.uk/pdbsum/1tow PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1tow RCSB]</span>
+
-
}}
+
'''Crystal structure of human adipocyte fatty acid binding protein in complex with a carboxylic acid ligand'''
'''Crystal structure of human adipocyte fatty acid binding protein in complex with a carboxylic acid ligand'''
Line 34: Line 31:
[[Category: Svensson, S.]]
[[Category: Svensson, S.]]
[[Category: Uppenberg, J.]]
[[Category: Uppenberg, J.]]
-
[[Category: lipid-binding]]
+
[[Category: Lipid-binding]]
-
[[Category: transport]]
+
[[Category: Transport]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:12:15 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:59:05 2008''
+

Revision as of 07:12, 3 May 2008

Image:1tow.gif

Template:STRUCTURE 1tow

Crystal structure of human adipocyte fatty acid binding protein in complex with a carboxylic acid ligand


Overview

Low micromolar human A-FABP inhibitors were found by utilizing a fluorescence polarization assay, X-ray crystallography and modeling. The carbazole- and indole-based inhibitors displayed approximately 10-fold preferences over human H-FABP and E-FABP, and are highly selective against I-FABP. This communication describes the SAR for drug-like synthetic inhibitors of human A-FABP.

About this Structure

1TOW is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target., Lehmann F, Haile S, Axen E, Medina C, Uppenberg J, Svensson S, Lundback T, Rondahl L, Barf T, Bioorg Med Chem Lett. 2004 Sep 6;14(17):4445-8. PMID:15357969 Page seeded by OCA on Sat May 3 10:12:15 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1tow"
Personal tools