1tpz

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[[Image:1tpz.jpg|left|200px]]
[[Image:1tpz.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1tpz |SIZE=350|CAPTION= <scene name='initialview01'>1tpz</scene>, resolution 2.0&Aring;
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The line below this paragraph, containing "STRUCTURE_1tpz", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GDP:GUANOSINE-5&#39;-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= IIGP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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-->
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|DOMAIN=
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{{STRUCTURE_1tpz| PDB=1tpz | SCENE= }}
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|RELATEDENTRY=[[1tqd|1TQD]], [[1tq2|1TQ2]], [[1tq4|1TQ4]], [[1tq6|1TQ6]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tpz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tpz OCA], [http://www.ebi.ac.uk/pdbsum/1tpz PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1tpz RCSB]</span>
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}}
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'''Crystal Structure of IIGP1: a paradigm for interferon inducible p47 resistance GTPases'''
'''Crystal Structure of IIGP1: a paradigm for interferon inducible p47 resistance GTPases'''
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[[Category: Uthaiah, R.]]
[[Category: Uthaiah, R.]]
[[Category: Wolf, E.]]
[[Category: Wolf, E.]]
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[[Category: crystal structure]]
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[[Category: Crystal structure]]
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[[Category: dimer]]
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[[Category: Dimer]]
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[[Category: gtpase]]
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[[Category: Gtpase]]
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[[Category: immunology]]
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[[Category: Immunology]]
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[[Category: interferon gamma]]
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[[Category: Interferon gamma]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:14:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:59:31 2008''
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Revision as of 07:14, 3 May 2008

Image:1tpz.jpg

Template:STRUCTURE 1tpz

Crystal Structure of IIGP1: a paradigm for interferon inducible p47 resistance GTPases


Overview

Interferon-inducible p47 GTPases are critical mediators of cell-autonomous resistance against several intracellular pathogens. Here we present the first crystal structure of a member of this novel GTPase family, IIGP1, in its nucleotide-free, GDP-, and GppNHp-bound form. The structure shows a Ras-like G domain between an N-terminal three-helix bundle and a complex system of C-terminal helices and loops. Sequence comparison and secondary structure prediction suggest the IIGP1 structure to be a valid model for the p47 GTPase family. The IIGP1 crystals contain a noncrystallographic dimer. We show that the dimer is required for cooperative GTP hydrolysis and GTP-dependent oligomerization of IIGP1. We also present the GDP- and GppNHp-bound monomeric structures of two dimer interface mutants. Our structures direct approaches to the analysis of the catalytic mechanism of IIGP1 and provide a coherent basis for structure-function studies aimed at elucidating the mechanistic basis of pathogen resistance caused by these enigmatic GTPases.

About this Structure

1TPZ is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of IIGP1: a paradigm for interferon-inducible p47 resistance GTPases., Ghosh A, Uthaiah R, Howard J, Herrmann C, Wolf E, Mol Cell. 2004 Sep 10;15(5):727-39. PMID:15350217 Page seeded by OCA on Sat May 3 10:14:10 2008

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