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4ala
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4ala]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_3 Dengue virus 3] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ALA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ALA FirstGlance]. <br> | <table><tr><td colspan='2'>[[4ala]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_3 Dengue virus 3] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ALA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ALA FirstGlance]. <br> | ||
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.84Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ala FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ala OCA], [https://pdbe.org/4ala PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ala RCSB], [https://www.ebi.ac.uk/pdbsum/4ala PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ala ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ala FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ala OCA], [https://pdbe.org/4ala PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ala RCSB], [https://www.ebi.ac.uk/pdbsum/4ala PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ala ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/Q7TGD1_9FLAV Q7TGD1_9FLAV] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774] | |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Flanagan | + | [[Category: Flanagan A]] |
| - | [[Category: Grimes | + | [[Category: Grimes JM]] |
| - | [[Category: Midgley | + | [[Category: Midgley CM]] |
| - | [[Category: Mongkolsapaya | + | [[Category: Mongkolsapaya J]] |
| - | [[Category: Screaton | + | [[Category: Screaton GR]] |
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Current revision
Structure of Dengue virus DIII in complex with Fab 2H12
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