6b2q

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Current revision (09:43, 23 October 2024) (edit) (undo)
 
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<StructureSection load='6b2q' size='340' side='right'caption='[[6b2q]], [[Resolution|resolution]] 2.88&Aring;' scene=''>
<StructureSection load='6b2q' size='340' side='right'caption='[[6b2q]], [[Resolution|resolution]] 2.88&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6b2q]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B2Q OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6B2Q FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6b2q]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B2Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6B2Q FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0BD:3-METHYL-1-(2-METHYLPROPYL)BUTYL+4-O-BETA-L-GULOPYRANOSYL-BETA-D-GLUCOPYRANOSIDE'>0BD</scene>, <scene name='pdbligand=CJJ:5-{5-chloro-4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl}thiophene-2-sulfonamide'>CJJ</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.88&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0BD:3-METHYL-1-(2-METHYLPROPYL)BUTYL+4-O-BETA-L-GULOPYRANOSYL-BETA-D-GLUCOPYRANOSIDE'>0BD</scene>, <scene name='pdbligand=CJJ:5-[5-chloranyl-4-[(5-cyclopropyl-1~{H}-pyrazol-3-yl)amino]pyrimidin-2-yl]thiophene-2-sulfonamide'>CJJ</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6b2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b2q OCA], [https://pdbe.org/6b2q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6b2q RCSB], [https://www.ebi.ac.uk/pdbsum/6b2q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6b2q ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6b2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b2q OCA], [http://pdbe.org/6b2q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6b2q RCSB], [http://www.ebi.ac.uk/pdbsum/6b2q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6b2q ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PKNA_MYCTA PKNA_MYCTA]] Protein kinase that regulates many aspects of mycobacterial physiology. Is a key component of a signal transduction pathway that regulates cell growth, cell shape and cell division via phosphorylation of target proteins such as FtsZ and MurD. Shows a strong preference for Thr versus Ser as the phosphoacceptor.<ref>PMID:11856348</ref> <ref>PMID:17068335</ref> <ref>PMID:18557704</ref>
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[https://www.uniprot.org/uniprot/PKNA_MYCTU PKNA_MYCTU] Key component of a signal transduction pathway that regulates cell growth and cell division via phosphorylation of target proteins such as FtsZ, Wag31, GlmU, FhaB, PstP, EmbR and Rv1422. Shows a strong preference for Thr versus Ser as the phosphoacceptor.<ref>PMID:15985609</ref> <ref>PMID:16817899</ref> <ref>PMID:19121323</ref> <ref>PMID:20066037</ref> <ref>PMID:21190553</ref> <ref>PMID:21423706</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Zuccola, H J]]
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[[Category: Zuccola HJ]]
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[[Category: Drug design]]
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[[Category: Kinase]]
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[[Category: Transferase-inhibitor complex]]
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[[Category: Tuberculosis]]
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Current revision

Dual Inhibition of the Essential Protein Kinases A and B in Mycobacterium tuberculosis

PDB ID 6b2q

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