1tqy

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1tqy.gif|left|200px]]
[[Image:1tqy.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1tqy |SIZE=350|CAPTION= <scene name='initialview01'>1tqy</scene>, resolution 2.00&Aring;
+
The line below this paragraph, containing "STRUCTURE_1tqy", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-ketoacyl-acyl-carrier-protein_synthase_I Beta-ketoacyl-acyl-carrier-protein synthase I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.41 2.3.1.41] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE= SCO5087 and SCO5088 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2 Bacteria]), SCO5088, SCBAC28G1.14 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1902 Streptomyces coelicolor])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1tqy| PDB=1tqy | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tqy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tqy OCA], [http://www.ebi.ac.uk/pdbsum/1tqy PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1tqy RCSB]</span>
+
-
}}
+
'''The Actinorhodin Ketosynthase/Chain Length Factor'''
'''The Actinorhodin Ketosynthase/Chain Length Factor'''
Line 32: Line 29:
[[Category: Medzihradszky, K F.]]
[[Category: Medzihradszky, K F.]]
[[Category: Stroud, R M.]]
[[Category: Stroud, R M.]]
-
[[Category: alpha-beta-alpha-beta-alpha]]
+
[[Category: Alpha-beta-alpha-beta-alpha]]
-
[[Category: heterodimer]]
+
[[Category: Heterodimer]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:16:16 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:59:52 2008''
+

Revision as of 07:16, 3 May 2008

Image:1tqy.gif

Template:STRUCTURE 1tqy

The Actinorhodin Ketosynthase/Chain Length Factor


Overview

The synthesis of aromatic polyketides, such as actinorhodin, tetracycline and doxorubicin, begins with the formation of a polyketide chain. In type II polyketide synthases (PKSs), chains are polymerized by the heterodimeric ketosynthase-chain length factor (KS-CLF). Here we present the 2.0-A structure of the actinorhodin KS-CLF, which shows polyketides being elongated inside an amphipathic tunnel approximately 17 A in length at the heterodimer interface. The structure resolves many of the questions about the roles of KS and CLF. Although CLF regulates chain length, it does not have an active site; KS must catalyze both chain initiation and elongation. We provide evidence that the first cyclization of the polyketide occurs within the KS-CLF tunnel. The mechanistic details of this central PKS polymerase could guide biosynthetic chemists in designing new pharmaceuticals and polymers.

About this Structure

1TQY is a Protein complex structure of sequences from Bacteria and Streptomyces coelicolor. Full crystallographic information is available from OCA.

Reference

An antibiotic factory caught in action., Keatinge-Clay AT, Maltby DA, Medzihradszky KF, Khosla C, Stroud RM, Nat Struct Mol Biol. 2004 Sep;11(9):888-93. Epub 2004 Aug 1. PMID:15286722 Page seeded by OCA on Sat May 3 10:16:16 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1tqy"
Personal tools