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| | <StructureSection load='6elu' size='340' side='right'caption='[[6elu]], [[Resolution|resolution]] 2.30Å' scene=''> | | <StructureSection load='6elu' size='340' side='right'caption='[[6elu]], [[Resolution|resolution]] 2.30Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[6elu]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice] and [http://en.wikipedia.org/wiki/Trybr Trybr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ELU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ELU FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6elu]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Trypanosoma_brucei_rhodesiense Trypanosoma brucei rhodesiense]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ELU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ELU FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SRA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=31286 TRYBR])</td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6elu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6elu OCA], [http://pdbe.org/6elu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6elu RCSB], [http://www.ebi.ac.uk/pdbsum/6elu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6elu ProSAT]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6elu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6elu OCA], [https://pdbe.org/6elu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6elu RCSB], [https://www.ebi.ac.uk/pdbsum/6elu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6elu ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | + | == Function == |
| | + | [https://www.uniprot.org/uniprot/Q8T309_TRYBR Q8T309_TRYBR] |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | </div> | | </div> |
| | <div class="pdbe-citations 6elu" style="background-color:#fffaf0;"></div> | | <div class="pdbe-citations 6elu" style="background-color:#fffaf0;"></div> |
| | + | |
| | + | ==See Also== |
| | + | *[[Antibody 3D structures|Antibody 3D structures]] |
| | == References == | | == References == |
| | <references/> | | <references/> |
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| | </StructureSection> | | </StructureSection> |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Lk3 transgenic mice]] | + | [[Category: Mus musculus]] |
| - | [[Category: Trybr]] | + | [[Category: Trypanosoma brucei rhodesiense]] |
| - | [[Category: Higgins, M K]] | + | [[Category: Higgins MK]] |
| - | [[Category: Zoll, S]] | + | [[Category: Zoll S]] |
| - | [[Category: Antitoxin]]
| + | |
| - | [[Category: Apolipoprotein li]]
| + | |
| - | [[Category: Innate immune evasion]]
| + | |
| - | [[Category: Sleeping sickness]]
| + | |
| - | [[Category: Sra]]
| + | |
| - | [[Category: Tryanosome]]
| + | |
| - | [[Category: Trypanolytic factor]]
| + | |
| Structural highlights
Function
Q8T309_TRYBR
Publication Abstract from PubMed
Only two trypanosome subspecies are able to cause human African trypanosomiasis. To establish an infection in human blood, they must overcome the innate immune system by resisting the toxic effects of trypanolytic factor 1 and trypanolytic factor 2 (refs. (1,2)). These lipoprotein complexes contain an active, pore-forming component, apolipoprotein L1 (ApoL1), that causes trypanosome cell death (3) . One of the two human-infective subspecies, Trypanosoma brucei rhodesiense, differs from non-infective trypanosomes solely by the presence of the serum resistance-associated protein, which binds directly to ApoL1 and blocks its pore-forming capacity(3-5). Since this interaction is the single critical event that renders T. b. rhodesiense human- infective, detailed structural information that allows identification of binding determinants is crucial to understand immune escape by the parasite. Here, we present the structure of serum resistance-associated protein and reveal the adaptations that occurred as it diverged from other trypanosome surface molecules to neutralize ApoL1. We also present our mapping of residues important for ApoL1 binding, giving molecular insight into this interaction at the heart of human sleeping sickness.
The structure of serum resistance-associated protein and its implications for human African trypanosomiasis.,Zoll S, Lane-Serff H, Mehmood S, Schneider J, Robinson CV, Carrington M, Higgins MK Nat Microbiol. 2018 Jan 22. pii: 10.1038/s41564-017-0085-3. doi:, 10.1038/s41564-017-0085-3. PMID:29358741[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Zoll S, Lane-Serff H, Mehmood S, Schneider J, Robinson CV, Carrington M, Higgins MK. The structure of serum resistance-associated protein and its implications for human African trypanosomiasis. Nat Microbiol. 2018 Jan 22. pii: 10.1038/s41564-017-0085-3. doi:, 10.1038/s41564-017-0085-3. PMID:29358741 doi:http://dx.doi.org/10.1038/s41564-017-0085-3
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