6gbu

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==Crystal structure of the second SH3 domain of FCHSD2 (SH3-2) in complex with the fourth SH3 domain of ITSN1 (SH3d)==
==Crystal structure of the second SH3 domain of FCHSD2 (SH3-2) in complex with the fourth SH3 domain of ITSN1 (SH3d)==
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<StructureSection load='6gbu' size='340' side='right' caption='[[6gbu]], [[Resolution|resolution]] 3.44&Aring;' scene=''>
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<StructureSection load='6gbu' size='340' side='right'caption='[[6gbu]], [[Resolution|resolution]] 3.44&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6gbu]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GBU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GBU FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6gbu]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GBU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6GBU FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FCHSD2, KIAA0769, SH3MD3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), ITSN1, ITSN, SH3D1A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.44&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gbu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gbu OCA], [http://pdbe.org/6gbu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gbu RCSB], [http://www.ebi.ac.uk/pdbsum/6gbu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gbu ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6gbu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gbu OCA], [https://pdbe.org/6gbu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6gbu RCSB], [https://www.ebi.ac.uk/pdbsum/6gbu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6gbu ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ITSN1_HUMAN ITSN1_HUMAN]] Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1.<ref>PMID:11744688</ref> <ref>PMID:22648170</ref>
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[https://www.uniprot.org/uniprot/FCSD2_HUMAN FCSD2_HUMAN]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6gbu" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6gbu" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Intersectin|Intersectin]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Almeida-Souza, L]]
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[[Category: Large Structures]]
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[[Category: Andrews, B]]
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[[Category: Almeida-Souza L]]
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[[Category: Colussi, A]]
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[[Category: Andrews B]]
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[[Category: Frank, R]]
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[[Category: Colussi A]]
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[[Category: Garcia-Nafria, J]]
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[[Category: Frank R]]
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[[Category: Gunawardana, N]]
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[[Category: Garcia-Nafria J]]
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[[Category: Howard, G]]
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[[Category: Gunawardana N]]
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[[Category: Johnson, C M]]
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[[Category: Howard G]]
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[[Category: McMahon, H T]]
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[[Category: Johnson CM]]
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[[Category: Vallis, Y]]
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[[Category: McMahon HT]]
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[[Category: Yu, M]]
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[[Category: Vallis Y]]
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[[Category: Endocytosis]]
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[[Category: Yu M]]
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[[Category: Sh3-sh3 complex]]
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Current revision

Crystal structure of the second SH3 domain of FCHSD2 (SH3-2) in complex with the fourth SH3 domain of ITSN1 (SH3d)

PDB ID 6gbu

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