6irb

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Current revision (10:04, 23 October 2024) (edit) (undo)
 
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<StructureSection load='6irb' size='340' side='right'caption='[[6irb]], [[Resolution|resolution]] 2.66&Aring;' scene=''>
<StructureSection load='6irb' size='340' side='right'caption='[[6irb]], [[Resolution|resolution]] 2.66&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6irb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IRB OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6IRB FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6irb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IRB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IRB FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.661&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">norpA, PLC-beta, CG3620 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoinositide_phospholipase_C Phosphoinositide phospholipase C], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.11 3.1.4.11] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6irb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6irb OCA], [https://pdbe.org/6irb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6irb RCSB], [https://www.ebi.ac.uk/pdbsum/6irb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6irb ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6irb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6irb OCA], [http://pdbe.org/6irb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6irb RCSB], [http://www.ebi.ac.uk/pdbsum/6irb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6irb ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PIPA_DROME PIPA_DROME]] The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (By similarity). Essential component of the phototransduction pathway (PubMed:2457447). Essential downstream component of a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required for the activation of Cad99C and consequently Cad99C-dependent endosome formation, which is essential for the Duox-dependent production of reactive oxygen species (ROS) in response to intestinal bacterial infection (PubMed:25639794).[UniProtKB:Q9P212]<ref>PMID:2457447</ref> <ref>PMID:25639794</ref>
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[https://www.uniprot.org/uniprot/PIPA_DROME PIPA_DROME] The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (By similarity). Essential component of the phototransduction pathway (PubMed:2457447). Essential downstream component of a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required for the activation of Cad99C and consequently Cad99C-dependent endosome formation, which is essential for the Duox-dependent production of reactive oxygen species (ROS) in response to intestinal bacterial infection (PubMed:25639794).[UniProtKB:Q9P212]<ref>PMID:2457447</ref> <ref>PMID:25639794</ref>
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Drome]]
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[[Category: Drosophila melanogaster]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Phosphoinositide phospholipase C]]
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[[Category: Huang Y]]
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[[Category: Huang, Y]]
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[[Category: Li J]]
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[[Category: Li, J]]
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[[Category: Liu W]]
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[[Category: Liu, W]]
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[[Category: Ye F]]
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[[Category: Ye, F]]
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[[Category: Zhang M]]
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[[Category: Zhang, M]]
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[[Category: Coiled coil]]
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[[Category: Drosophila selenomethionine]]
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[[Category: Hydrolase]]
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[[Category: Phospholipase c beta]]
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Current revision

C-terminal coiled coil domain of Drosophila phospholipase C beta NORPA, selenomethionine

PDB ID 6irb

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