6kn2
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[6kn2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_zonatus Conus zonatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KN2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6KN2 FirstGlance]. <br> | <table><tr><td colspan='2'>[[6kn2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_zonatus Conus zonatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KN2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6KN2 FirstGlance]. <br> | ||
- | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 27 models</td></tr> |
+ | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6kn2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kn2 OCA], [https://pdbe.org/6kn2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6kn2 RCSB], [https://www.ebi.ac.uk/pdbsum/6kn2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6kn2 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6kn2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kn2 OCA], [https://pdbe.org/6kn2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6kn2 RCSB], [https://www.ebi.ac.uk/pdbsum/6kn2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6kn2 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
- | [https://www.uniprot.org/uniprot/CX07_CONZO CX07_CONZO] | + | [https://www.uniprot.org/uniprot/CX07_CONZO CX07_CONZO] Inhibits the human alpha-3-beta-4/CHRNA3-CHRNB4 (IC(50)=15.7 uM) and alpha-7/CHRNA7 (IC(50)=77.2 uM) nicotinic acetylcholine receptor (nAChR) (PubMed:32234761). Incomplete inhibition of responses is observed for both subtypes, indicating a potential non-competitive mode of action (PubMed:32234761).<ref>PMID:32234761</ref> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == |
Current revision
Structure of single disulfide peptide Czon1107-WT (major conformer)
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