6kn2

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6kn2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_zonatus Conus zonatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KN2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6KN2 FirstGlance]. <br>
<table><tr><td colspan='2'>[[6kn2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_zonatus Conus zonatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KN2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6KN2 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 27 models</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6kn2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kn2 OCA], [https://pdbe.org/6kn2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6kn2 RCSB], [https://www.ebi.ac.uk/pdbsum/6kn2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6kn2 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6kn2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kn2 OCA], [https://pdbe.org/6kn2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6kn2 RCSB], [https://www.ebi.ac.uk/pdbsum/6kn2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6kn2 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[https://www.uniprot.org/uniprot/CX07_CONZO CX07_CONZO]
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[https://www.uniprot.org/uniprot/CX07_CONZO CX07_CONZO] Inhibits the human alpha-3-beta-4/CHRNA3-CHRNB4 (IC(50)=15.7 uM) and alpha-7/CHRNA7 (IC(50)=77.2 uM) nicotinic acetylcholine receptor (nAChR) (PubMed:32234761). Incomplete inhibition of responses is observed for both subtypes, indicating a potential non-competitive mode of action (PubMed:32234761).<ref>PMID:32234761</ref>
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==

Current revision

Structure of single disulfide peptide Czon1107-WT (major conformer)

PDB ID 6kn2

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