1trr

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[[Image:1trr.gif|left|200px]]
[[Image:1trr.gif|left|200px]]
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{{Structure
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|PDB= 1trr |SIZE=350|CAPTION= <scene name='initialview01'>1trr</scene>, resolution 2.400&Aring;
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The line below this paragraph, containing "STRUCTURE_1trr", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=TRP:TRYPTOPHAN'>TRP</scene>
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{{STRUCTURE_1trr| PDB=1trr | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1trr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1trr OCA], [http://www.ebi.ac.uk/pdbsum/1trr PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1trr RCSB]</span>
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'''TANDEM BINDING IN CRYSTALS OF A TRP REPRESSOR/OPERATOR HALF-SITE COMPLEX'''
'''TANDEM BINDING IN CRYSTALS OF A TRP REPRESSOR/OPERATOR HALF-SITE COMPLEX'''
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[[Category: Carey, J.]]
[[Category: Carey, J.]]
[[Category: Lawson, C L.]]
[[Category: Lawson, C L.]]
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[[Category: protein-dna complex]]
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[[Category: Protein-dna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:17:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:00:12 2008''
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Revision as of 07:17, 3 May 2008

Image:1trr.gif

Template:STRUCTURE 1trr

TANDEM BINDING IN CRYSTALS OF A TRP REPRESSOR/OPERATOR HALF-SITE COMPLEX


Overview

The crystal structure of trp repressor tandemly bound in a 2:1 complex to a 16-base-pair palindromic DNA containing a central trp operator half-site has been determined and refined to 2.4 A resolution. Despite dramatically different DNA sequence contexts and crystallization conditions, the protein/DNA interface is essentially identical to that seen in the original trp repressor/operator complex structure. Water-mediated sequence recognition by trp repressor is likely to be related to the unusual end-on approach of the recognition helix (E), which allows sharing of the major groove by tandem dimers. The tandem complex model accounts for the mutational sensitivity of all trp operator base pairs. The structure also provides the first detailed view of the tandem interaction, revealing a key role for the amino-terminal arms.

About this Structure

1TRR is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Tandem binding in crystals of a trp repressor/operator half-site complex., Lawson CL, Carey J, Nature. 1993 Nov 11;366(6451):178-82. PMID:8232559 Page seeded by OCA on Sat May 3 10:17:53 2008

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