1ts3
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:1ts3.gif|left|200px]] | [[Image:1ts3.gif|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_1ts3", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | | | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), |
| - | | | + | or leave the SCENE parameter empty for the default display. |
| - | + | --> | |
| - | + | {{STRUCTURE_1ts3| PDB=1ts3 | SCENE= }} | |
| - | + | ||
| - | + | ||
| - | }} | + | |
'''H135A MUTANT OF TOXIC SHOCK SYNDROME TOXIN-1 FROM S. AUREUS''' | '''H135A MUTANT OF TOXIC SHOCK SYNDROME TOXIN-1 FROM S. AUREUS''' | ||
| Line 32: | Line 29: | ||
[[Category: Pinheiro, D M.]] | [[Category: Pinheiro, D M.]] | ||
[[Category: Schlievert, P M.]] | [[Category: Schlievert, P M.]] | ||
| - | [[Category: | + | [[Category: Superantigen]] |
| - | [[Category: | + | [[Category: Toxin]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:18:13 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 07:18, 3 May 2008
H135A MUTANT OF TOXIC SHOCK SYNDROME TOXIN-1 FROM S. AUREUS
Overview
The three-dimensional structures of five mutants of toxic shock syndrome toxin-1 (TSST-1) have been determined. These mutations are in the long central alpha helix and are useful in mapping portions of TSST-1 involved in superantigenicity and lethality. The T128A, H135A, Q139K, and I140T mutations appear to reduce superantigenicity by altering the properties of the T-cell receptor interaction surface. The Q136A mutation is at a largely buried site and causes a dramatic change in the conformation of the beta7-beta9 loop which covers the back of the central alpha helix. As this mutation has the unique ability to reduce the toxin's lethality in rabbits while retaining its superantigenicity, it raises the possibility that this rear loop mediates the ability of TSST-1 to induce lethality and suggests a route for producing nonlethal toxins for therapeutic development.
About this Structure
1TS3 is a Single protein structure of sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.
Reference
Structures of five mutants of toxic shock syndrome toxin-1 with reduced biological activity., Earhart CA, Mitchell DT, Murray DL, Pinheiro DM, Matsumura M, Schlievert PM, Ohlendorf DH, Biochemistry. 1998 May 19;37(20):7194-202. PMID:9585531 Page seeded by OCA on Sat May 3 10:18:13 2008
