7jqe

<table><tr><td colspan='2'>[[7jqe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Strg1 Strg1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JQE OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7JQE FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>

<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>

<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">esaA, SGGB_0524 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=981539 STRG1])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7jqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jqe OCA], [http://pdbe.org/7jqe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7jqe RCSB], [http://www.ebi.ac.uk/pdbsum/7jqe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7jqe ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

Gram-positive bacteria use type VII secretion systems (T7SSs) to export effector proteins that manipulate the physiology of nearby prokaryotic and eukaryotic cells. Several mycobacterial T7SSs have established roles in virulence. By contrast, the genetically distinct T7SSb pathway found in Firmicutes bacteria more often functions to mediate bacterial competition. A lack of structural information on the T7SSb has limited the understanding of effector export by this protein secretion apparatus. Here, we present the 2.4 A crystal structure of the extracellular region of the T7SSb subunit EsaA from Streptococcus gallolyticus. Our structure reveals that homodimeric EsaA is an elongated, arrow-shaped protein with a surface-accessible "tip", which in some species of bacteria serves as a receptor for lytic bacteriophages. Because it is the only T7SSb subunit large enough to traverse the peptidoglycan layer of Firmicutes, we propose that EsaA plays a critical role in transporting effectors across the entirety of the Gram-positive cell envelope.

Structure of the Extracellular Region of the Bacterial Type VIIb Secretion System Subunit EsaA.,Klein TA, Grebenc DW, Gandhi SY, Shah VS, Kim Y, Whitney JC Structure. 2020 Nov 16. pii: S0969-2126(20)30414-7. doi:, 10.1016/j.str.2020.11.002. PMID:33238147<ref>PMID:33238147</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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== References ==

<references/>

[[Category: Grebenc, D W]]

[[Category: Kim, Y]]

[[Category: Klein, T A]]

[[Category: Whitney, J C]]

[[Category: Protein transport]]