7p4x
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
<StructureSection load='7p4x' size='340' side='right'caption='[[7p4x]]' scene=''> | <StructureSection load='7p4x' size='340' side='right'caption='[[7p4x]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'> | + | <table><tr><td colspan='2'>Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7P4X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7P4X FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7p4x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7p4x OCA], [https://pdbe.org/7p4x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7p4x RCSB], [https://www.ebi.ac.uk/pdbsum/7p4x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7p4x ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7p4x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7p4x OCA], [https://pdbe.org/7p4x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7p4x RCSB], [https://www.ebi.ac.uk/pdbsum/7p4x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7p4x ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | == Function == | ||
| - | [https://www.uniprot.org/uniprot/PACA_LITCT PACA_LITCT] Antibacterial peptide with amphipathic alpha-helical structure that exhibits potent broad-spectrum activity against Gram-positive and -negative bacteria (Ref.1, PubMed:34789753). It is active against Listeria ATCC 54004 (MIC=30 ug/ml), S.aureus ATCC 25923 (MIC=7.8 ug/ml), S.suis 2 CVCC 606 (MIC=31.25 ug/ml), B.subtilis ADB403 (30 ug/ml), K.pneumoniae ATCC 700603 (MIC=60 ug/ml) and P. aeruginosa ATCC 227853 (MIC=30 ug/ml) (Ref.1). Does not show activity against Salmonella ATCC 20020 and the fungus Candida albicans (Ref.1). Is also cytotoxic to HeLa cells at high concentrations (Ref.1). In addition, shows a strong antitumor activity but only a little hemolytic activity (Ref.1). Despite the presence of a Gly residue at position 10, this alpha-helical peptide remains relatively rigid, not exhibiting any significant flexibility during the molecular dynamics simulation (PubMed:34789753). The peptide shows a preference for a position parallel to the target membrane that suggests it exerts its antimicrobial activity through a non-pore-forming mechanism of action, such as the carpet model or the interfacial activity model (PubMed:34789753).<ref>PMID:34789753</ref> [REFERENCE:1] | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 22: | Line 21: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Lithobates catesbeianus]] | ||
[[Category: Hewage CM]] | [[Category: Hewage CM]] | ||
[[Category: Timmons PB]] | [[Category: Timmons PB]] | ||
Current revision
SOLUTION NMR STRUCTURE OF PALUSTRIN-CA IN 50% TRIFLUOROETHANOL
| |||||||||||
