7qvm
From Proteopedia
(Difference between revisions)
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| - | ==== | + | ==Human Oxytocin receptor (OTR) oxytocin Gq chimera (mGoqi) complex== |
| - | <StructureSection load='7qvm' size='340' side='right'caption='[[7qvm]]' scene=''> | + | <StructureSection load='7qvm' size='340' side='right'caption='[[7qvm]], [[Resolution|resolution]] 3.25Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7qvm]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QVM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QVM FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qvm OCA], [https://pdbe.org/7qvm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qvm RCSB], [https://www.ebi.ac.uk/pdbsum/7qvm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qvm ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.25Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qvm OCA], [https://pdbe.org/7qvm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qvm RCSB], [https://www.ebi.ac.uk/pdbsum/7qvm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qvm ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/GNAO_HUMAN GNAO_HUMAN] Early infantile epileptic encephalopathy. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GNAO_HUMAN GNAO_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The small cyclic neuropeptide hormone oxytocin (OT) and its cognate receptor play a central role in the regulation of social behaviour and sexual reproduction. Here we report the single-particle cryo-electron microscopy structure of the active oxytocin receptor (OTR) in complex with its cognate ligand oxytocin. Our structure provides high-resolution insights into the OT binding mode, the OTR activation mechanism as well as the subtype specificity within the oxytocin/vasopressin receptor family. | ||
| + | |||
| + | Structural basis for the activation and ligand recognition of the human oxytocin receptor.,Waltenspuhl Y, Ehrenmann J, Vacca S, Thom C, Medalia O, Pluckthun A Nat Commun. 2022 Jul 18;13(1):4153. doi: 10.1038/s41467-022-31325-0. PMID:35851571<ref>PMID:35851571</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7qvm" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Transducin 3D structures|Transducin 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Mus musculus]] |
| + | [[Category: Ehrenmann J]] | ||
| + | [[Category: Medalia O]] | ||
| + | [[Category: Pluckthun A]] | ||
| + | [[Category: Thom C]] | ||
| + | [[Category: Vacca S]] | ||
| + | [[Category: Waltenspuhl Y]] | ||
Current revision
Human Oxytocin receptor (OTR) oxytocin Gq chimera (mGoqi) complex
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