7r85
From Proteopedia
(Difference between revisions)
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<StructureSection load='7r85' size='340' side='right'caption='[[7r85]], [[Resolution|resolution]] 1.45Å' scene=''> | <StructureSection load='7r85' size='340' side='right'caption='[[7r85]], [[Resolution|resolution]] 1.45Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'> | + | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R85 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R85 FirstGlance]. <br> |
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45Å</td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr> | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r85 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r85 OCA], [https://pdbe.org/7r85 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r85 RCSB], [https://www.ebi.ac.uk/pdbsum/7r85 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r85 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r85 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r85 OCA], [https://pdbe.org/7r85 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r85 RCSB], [https://www.ebi.ac.uk/pdbsum/7r85 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r85 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | == Function == | ||
| - | [https://www.uniprot.org/uniprot/AGRB1_MOUSE AGRB1_MOUSE] Phosphatidylserine receptor which enhances the engulfment of apoptotic cells (PubMed:17960134). Also mediates the binding and engulfment of Gram-negative bacteria (PubMed:21245295, PubMed:26838550, PubMed:26838550). Stimulates production of reactive oxygen species by macrophages in response to Gram-negative bacteria, resulting in enhanced microbicidal macrophage activity (By similarity). In the gastric mucosa, required for recognition and engulfment of apoptotic gastric epithelial cells (By similarity). Promotes myoblast fusion (PubMed:23615608). Activates the Rho pathway in a G-protein-dependent manner (By similarity). Inhibits MDM2-mediated ubiquitination and degradation of DLG4/PSD95, promoting DLG4 stability and regulating synaptic plasticity (PubMed:25751059). Required for the formation of dendritic spines by ensuring the correct localization of PARD3 and TIAM1 (By similarity). Potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53/TP53 signal in suppression of glioblastoma (By similarity).[UniProtKB:C0HL12][UniProtKB:O14514]<ref>PMID:11875720</ref> <ref>PMID:17960134</ref> <ref>PMID:21245295</ref> <ref>PMID:23615608</ref> <ref>PMID:25751059</ref> <ref>PMID:26838550</ref> Inhibits angiogenesis in a CD36-dependent manner.[UniProtKB:O14514] Inhibits angiogenesis.[UniProtKB:O14514] | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Mus musculus]] | ||
[[Category: Garcia KC]] | [[Category: Garcia KC]] | ||
[[Category: Jude KM]] | [[Category: Jude KM]] | ||
[[Category: Miao Y]] | [[Category: Miao Y]] | ||
Current revision
Structure of mouse Bai1 (ADGRB1) TSR3 domain
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