7z5g
From Proteopedia
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==human apo MATCAP== | ==human apo MATCAP== | ||
| - | <StructureSection load='7z5g' size='340' side='right'caption='[[7z5g]]' scene=''> | + | <StructureSection load='7z5g' size='340' side='right'caption='[[7z5g]], [[Resolution|resolution]] 2.11Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Z5G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Z5G FirstGlance]. <br> | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Z5G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Z5G FirstGlance]. <br> | ||
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7z5g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7z5g OCA], [https://pdbe.org/7z5g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7z5g RCSB], [https://www.ebi.ac.uk/pdbsum/7z5g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7z5g ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.113Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7z5g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7z5g OCA], [https://pdbe.org/7z5g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7z5g RCSB], [https://www.ebi.ac.uk/pdbsum/7z5g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7z5g ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The detyrosination-tyrosination cycle involves the removal and re-ligation of the C-terminal tyrosine of alpha-tubulin and is implicated in cognitive, cardiac, and mitotic defects. The Vasohibin-SVBP complex underlies much, but not all, detyrosination. Here, we used haploid genetic screens to identify an unannotated protein, MATCAP, as a remaining detyrosinating enzyme. X-ray crystallography and cryo-EM structures established MATCAP's cleaving mechanism, substrate specificity, and microtubule recognition. Paradoxically, while abrogation of tyrosine re-ligation is lethal in mice, co-deletion of MATCAP and SVBP was not. Although viable, defective detyrosination caused microcephaly associated with proliferative defects during neurogenesis, and abnormal behavior. Thus, MATCAP is a missing component of the detyrosination-tyrosination cycle, revealing the importance of this modification in brain formation. | ||
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| + | Posttranslational modification of microtubules by the MATCAP detyrosinase.,Landskron L, Bak J, Adamopoulos A, Kaplani K, Moraiti M, van den Hengel LG, Song JY, Bleijerveld OB, Nieuwenhuis J, Heidebrecht T, Henneman L, Moutin MJ, Barisic M, Taraviras S, Perrakis A, Brummelkamp TR Science. 2022 Apr 28:eabn6020. doi: 10.1126/science.abn6020. PMID:35482892<ref>PMID:35482892</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7z5g" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Current revision
human apo MATCAP
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