1ttu

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[[Image:1ttu.gif|left|200px]]
[[Image:1ttu.gif|left|200px]]
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{{Structure
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|PDB= 1ttu |SIZE=350|CAPTION= <scene name='initialview01'>1ttu</scene>, resolution 2.85&Aring;
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The line below this paragraph, containing "STRUCTURE_1ttu", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>
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|GENE= lag-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 Caenorhabditis elegans])
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|DOMAIN=
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{{STRUCTURE_1ttu| PDB=1ttu | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ttu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ttu OCA], [http://www.ebi.ac.uk/pdbsum/1ttu PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ttu RCSB]</span>
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'''Crystal Structure of CSL bound to DNA'''
'''Crystal Structure of CSL bound to DNA'''
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[[Category: Hendrickson, W A.]]
[[Category: Hendrickson, W A.]]
[[Category: Kovall, R A.]]
[[Category: Kovall, R A.]]
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[[Category: beta-trefoil domain]]
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[[Category: Beta-trefoil domain]]
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[[Category: csl]]
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[[Category: Csl]]
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[[Category: notch signaling]]
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[[Category: Notch signaling]]
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[[Category: protein-dna complex]]
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[[Category: Protein-dna complex]]
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[[Category: rel homology region]]
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[[Category: Rel homology region]]
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[[Category: transcription factor]]
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[[Category: Transcription factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:21:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:01:02 2008''
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Revision as of 07:21, 3 May 2008

Image:1ttu.gif

Template:STRUCTURE 1ttu

Crystal Structure of CSL bound to DNA


Overview

Notch signaling is a conserved pathway of communication between neighboring cells that results in cell fate specification, and CSL is the universal transcriptional effector of Notch signaling. The Notch intracellular domain translocates to the nucleus after proteolytic release upon Notch extracellular engagement, and there it displaces corepressors from DNA-bound CSL and recruits activators of Notch target genes. Here we report the 2.85 A crystal structure of CSL with a target DNA. CSL comprises three structurally integrated domains: its amino (NTD)- and carboxy (CTD)-terminal domains are strikingly similar to those of Rel transcription factors, but a surprising beta-trefoil domain (BTD) is inserted between them. CSL-bound DNA is recognized specifically by conserved residues from NTD and BTD. A hydrophobic pocket on BTD is identified as the likely site of Notch interaction with CSL, which has functional implications for the mechanism of Notch signaling.

About this Structure

1TTU is a Single protein structure of sequence from Caenorhabditis elegans. Full crystallographic information is available from OCA.

Reference

Crystal structure of the nuclear effector of Notch signaling, CSL, bound to DNA., Kovall RA, Hendrickson WA, EMBO J. 2004 Sep 1;23(17):3441-51. Epub 2004 Aug 5. PMID:15297877 Page seeded by OCA on Sat May 3 10:21:22 2008

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