1tu5

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[[Image:1tu5.gif|left|200px]]
[[Image:1tu5.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1tu5 |SIZE=350|CAPTION= <scene name='initialview01'>1tu5</scene>, resolution 2.37&Aring;
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The line below this paragraph, containing "STRUCTURE_1tu5", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=TPQ:5-(2-CARBOXY-2-AMINOETHYL)-2-HYDROXY-1,4-BENZOQUINONE'>TPQ</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Amine_oxidase_(copper-containing) Amine oxidase (copper-containing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.6 1.4.3.6] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1tu5| PDB=1tu5 | SCENE= }}
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|RELATEDENTRY=[[1oac|1OAC]], [[1ksi|1KSI]], [[1n9e|1N9E]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tu5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tu5 OCA], [http://www.ebi.ac.uk/pdbsum/1tu5 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1tu5 RCSB]</span>
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}}
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'''Crystal structure of bovine plasma copper-containing amine oxidase'''
'''Crystal structure of bovine plasma copper-containing amine oxidase'''
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==Reference==
==Reference==
Crystal structure of amine oxidase from bovine serum., Lunelli M, Di Paolo ML, Biadene M, Calderone V, Battistutta R, Scarpa M, Rigo A, Zanotti G, J Mol Biol. 2005 Mar 4;346(4):991-1004. Epub 2005 Jan 25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15701511 15701511]
Crystal structure of amine oxidase from bovine serum., Lunelli M, Di Paolo ML, Biadene M, Calderone V, Battistutta R, Scarpa M, Rigo A, Zanotti G, J Mol Biol. 2005 Mar 4;346(4):991-1004. Epub 2005 Jan 25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15701511 15701511]
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[[Category: Amine oxidase (copper-containing)]]
 
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Scarpa, M.]]
[[Category: Scarpa, M.]]
[[Category: Zanotti, G.]]
[[Category: Zanotti, G.]]
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[[Category: amine oxidase]]
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[[Category: Amine oxidase]]
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[[Category: copper]]
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[[Category: Copper]]
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[[Category: oxidoreductase]]
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[[Category: Oxidoreductase]]
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[[Category: quinoenzyme]]
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[[Category: Quinoenzyme]]
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[[Category: tpq]]
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[[Category: Tpq]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:22:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:01:05 2008''
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Revision as of 07:22, 3 May 2008

Image:1tu5.gif

Template:STRUCTURE 1tu5

Crystal structure of bovine plasma copper-containing amine oxidase


Overview

Copper-containing amine oxidase extracted from bovine serum (BSAO) was crystallized and its three-dimensional structure at 2.37A resolution is described. The biological unit of BSAO is a homodimer, formed by two monomers related to each other by a non-crystallographic 2-fold axis. Each monomer is composed of three domains, similar to those of other amine oxidases from lower species. The two monomers are structurally equivalent, despite some minor differences at the two active sites. A large funnel allows access of substrates to the active-site; another cavity, accessible to the solvent, is also present between the two monomers; this second cavity could allow the entrance of molecular oxygen necessary for the oxidative reaction. Some sugar residues, bound to Asn, were still present and visible in the electron density map, in spite of the exhaustive deglycosylation necessary to grow the crystals. The comparison of the BSAO structure with those of other resolved AO structures shows strong dissimilarities in the architecture and charge distribution of the cavities leading to the active-site, possibly explaining the differences in substrate specificity.

About this Structure

1TU5 is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Crystal structure of amine oxidase from bovine serum., Lunelli M, Di Paolo ML, Biadene M, Calderone V, Battistutta R, Scarpa M, Rigo A, Zanotti G, J Mol Biol. 2005 Mar 4;346(4):991-1004. Epub 2005 Jan 25. PMID:15701511 Page seeded by OCA on Sat May 3 10:22:06 2008

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