1tuf

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1tuf.gif|left|200px]]
[[Image:1tuf.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1tuf |SIZE=350|CAPTION= <scene name='initialview01'>1tuf</scene>, resolution 2.40&Aring;
+
The line below this paragraph, containing "STRUCTURE_1tuf", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=AZ1:AZELAIC+ACID'>AZ1</scene>, <scene name='pdbligand=LLP:2-LYSINE(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHANE)'>LLP</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Diaminopimelate_decarboxylase Diaminopimelate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.20 4.1.1.20] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE= LYSA, MJ1097 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2190 Methanocaldococcus jannaschii])
+
-->
-
|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0019 LysA], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam00278 Orn_DAP_Arg_deC]</span>
+
{{STRUCTURE_1tuf| PDB=1tuf | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tuf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tuf OCA], [http://www.ebi.ac.uk/pdbsum/1tuf PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1tuf RCSB]</span>
+
-
}}
+
'''Crystal structure of Diaminopimelate Decarboxylase from m. jannaschi'''
'''Crystal structure of Diaminopimelate Decarboxylase from m. jannaschi'''
Line 35: Line 32:
[[Category: Ray, S R.]]
[[Category: Ray, S R.]]
[[Category: Tomasz, A.]]
[[Category: Tomasz, A.]]
-
[[Category: antibiotic resistance]]
+
[[Category: Antibiotic resistance]]
-
[[Category: diamnopimilate decarboxylase]]
+
[[Category: Diamnopimilate decarboxylase]]
-
[[Category: lysine biosynthesis]]
+
[[Category: Lysine biosynthesis]]
-
[[Category: new york structural genomix research consortium]]
+
[[Category: New york structural genomix research consortium]]
-
[[Category: nysgxrc]]
+
[[Category: Nysgxrc]]
-
[[Category: protein structure initiative]]
+
[[Category: Protein structure initiative]]
-
[[Category: psi]]
+
[[Category: Psi]]
-
[[Category: structural genomic]]
+
[[Category: Structural genomic]]
-
[[Category: t135]]
+
[[Category: T135]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:22:45 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:01:16 2008''
+

Revision as of 07:22, 3 May 2008

Image:1tuf.gif

Template:STRUCTURE 1tuf

Crystal structure of Diaminopimelate Decarboxylase from m. jannaschi


Overview

Cocrystal structures of Methanococcus jannaschii diaminopimelate decarboxylase (DAPDC) bound to a substrate analog, azelaic acid, and its L-lysine product have been determined at 2.6 A and 2.0 A, respectively. This PLP-dependent enzyme is responsible for the final step of L-lysine biosynthesis in bacteria and plays a role in beta-lactam antibiotic resistance in Staphylococcus aureus. Substrate specificity derives from recognition of the L-chiral center of diaminopimelate and a system of ionic "molecular rulers" that dictate substrate length. A coupled-enzyme assay system permitted measurement of kinetic parameters for recombinant DAPDCs and inhibition constants (K(i)) for azelaic acid (89 microM) and other substrate analogs. Implications for rational design of broad-spectrum antimicrobial agents targeted against DAPDCs of drug-resistant strains of bacterial pathogens, such as Staphylococcus aureus, are discussed.

About this Structure

1TUF is a Single protein structure of sequence from Methanocaldococcus jannaschii. Full crystallographic information is available from OCA.

Reference

Cocrystal structures of diaminopimelate decarboxylase: mechanism, evolution, and inhibition of an antibiotic resistance accessory factor., Ray SS, Bonanno JB, Rajashankar KR, Pinho MG, He G, De Lencastre H, Tomasz A, Burley SK, Structure. 2002 Nov;10(11):1499-508. PMID:12429091 Page seeded by OCA on Sat May 3 10:22:45 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1tuf"
Personal tools