Salbutamol
From Proteopedia
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<StructureSection load='' size='340' side='right' caption='Salbutamol' scene='96/968805/Cv/1'> | <StructureSection load='' size='340' side='right' caption='Salbutamol' scene='96/968805/Cv/1'> | ||
| - | Salbutamol, also known as albuterol and sold under the brand name Ventolin | + | Salbutamol, also known as albuterol and sold under the brand name Ventolin, is a medication that opens up the medium and large airways in the lungs. It is a short-acting β2 adrenergic receptor agonist which works by causing relaxation of airway smooth muscle. It is used to treat asthma, including asthma attacks, exercise-induced bronchoconstriction, and chronic obstructive pulmonary disease (COPD). See also [https://en.wikipedia.org/wiki/Salbutamol]. |
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| + | The β2 adrenergic receptor is found in smooth muscles throughout the body, especially in the lungs. It normally binds adrenaline, resulting in dialation of the bronchioles, which leads to increased oxygen intake. Salbutamol is an agonist, meaning it binds in the same place as adrenaline and stimulates the same response. | ||
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| + | The β2 adrenergic receptor has seven <scene name='96/968805/Hydrophobic_hydrophilic/1'> mostly hydrophobic </scene> alpha helices that cross the cell membrane. When shown in a <scene name='96/968805/N_to_c_rainbow/1'>N to C rainbow</scene> | ||
<scene name='96/968805/Overall/1'>Beta1-Adrenergic Receptor with bound partial agonist Salbutamol</scene> ([[2y04]]). | <scene name='96/968805/Overall/1'>Beta1-Adrenergic Receptor with bound partial agonist Salbutamol</scene> ([[2y04]]). | ||
| - | <scene name='96/968805/N_to_c_rainbow/1'>N to C rainbow</scene> | ||
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<scene name='96/968805/Binding_site/1'>Salbutamol binding site</scene>. The phenyl ring of the salbutamol is sandwiched by <scene name='96/968805/Hydrophobic_pocket/1'>hydrophobic residues</scene>, while the N and O in salbutamol form <scene name='96/968805/Hydrophobic_pocket/1'>hydrogen bonds</scene> with nearby asparagine (Asn) and aspartate (Asp) residues. | <scene name='96/968805/Binding_site/1'>Salbutamol binding site</scene>. The phenyl ring of the salbutamol is sandwiched by <scene name='96/968805/Hydrophobic_pocket/1'>hydrophobic residues</scene>, while the N and O in salbutamol form <scene name='96/968805/Hydrophobic_pocket/1'>hydrogen bonds</scene> with nearby asparagine (Asn) and aspartate (Asp) residues. | ||
Revision as of 03:02, 30 October 2024
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