8s6o

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Current revision (06:12, 30 October 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8s6o is ON HOLD until Paper Publication
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==Structure of MLLE3 in complex with PAMPL2==
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<StructureSection load='8s6o' size='340' side='right'caption='[[8s6o]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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Authors: Devan, S., Shanmugasundaram, S., Muentjes, K., Smits, S.H., Altegoer, F., Feldbruegge, M.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8s6o]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Ustilago_maydis Ustilago maydis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8S6O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8S6O FirstGlance]. <br>
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Description: Structure of MLLE3 in complex with PAMPL2
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8s6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8s6o OCA], [https://pdbe.org/8s6o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8s6o RCSB], [https://www.ebi.ac.uk/pdbsum/8s6o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8s6o ProSAT]</span></td></tr>
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[[Category: Feldbruegge, M]]
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</table>
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[[Category: Altegoer, F]]
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== Function ==
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[[Category: Shanmugasundaram, S]]
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[https://www.uniprot.org/uniprot/RRM4_USTMA RRM4_USTMA] Key RNA-binding protein involved in the formation of polar-growing hyphae which is essential for infection by the plant pathogen (PubMed:15643068, PubMed:17105762, PubMed:19494833). During filamentation, assembles into particles that shuttle bidirectionally along microtubules to both poles (PubMed:17105762, PubMed:19494833, PubMed:30738139). The RRM4 transport particles are part of the endosomal mRNP transport that regulates polarity of the infectious hyphae by transporting distinct mRNAs encoding, for example, the ubiquitin fusion protein UBI1, the small G protein RHO3, or the septin CDC3, from the nucleus to cell poles (PubMed:17105762, PubMed:19494833, PubMed:22357951, PubMed:24355572, PubMed:25985087, PubMed:30738139). Recognizes a broad spectrum of cargo mRNAs and precisely binds at stop codons, which constitute landmark sites of translation, suggesting an intimate connection of mRNA transport and translation (PubMed:30552148). Binds also to the specific binding motif UAUG of cargo mRNAs via its third RRM (PubMed:30552148). Plus-end-directed KIN3, a kinesin-3 type motor, mediates anterograde transport of RRM4-containing mRNPs whereas split dynein DYM1-DYN2 functions in retrograde movement of mRNPs (PubMed:22357951).<ref>PMID:15643068</ref> <ref>PMID:17105762</ref> <ref>PMID:19494833</ref> <ref>PMID:22357951</ref> <ref>PMID:24355572</ref> <ref>PMID:25985087</ref> <ref>PMID:30552148</ref> <ref>PMID:30738139</ref>
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[[Category: Devan, S]]
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== References ==
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[[Category: Smits, S.H]]
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<references/>
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[[Category: Muentjes, K]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Ustilago maydis]]
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[[Category: Altegoer F]]
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[[Category: Devan S]]
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[[Category: Feldbruegge M]]
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[[Category: Muentjes K]]
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[[Category: Shanmugasundaram S]]
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[[Category: Smits SH]]

Current revision

Structure of MLLE3 in complex with PAMPL2

PDB ID 8s6o

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OCA

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