1tvt

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[[Image:1tvt.jpg|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1tvt", creates the "Structure Box" on the page.
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|GENE= POTENTIAL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11665 Equine infectious anemia virus])
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{{STRUCTURE_1tvt| PDB=1tvt | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tvt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tvt OCA], [http://www.ebi.ac.uk/pdbsum/1tvt PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1tvt RCSB]</span>
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'''STRUCTURE OF THE EQUINE INFECTIOUS ANEMIA VIRUS TAT PROTEIN'''
'''STRUCTURE OF THE EQUINE INFECTIOUS ANEMIA VIRUS TAT PROTEIN'''
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[[Category: Roesch, P.]]
[[Category: Roesch, P.]]
[[Category: Willbold, D.]]
[[Category: Willbold, D.]]
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[[Category: transcription regulation]]
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[[Category: Transcription regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:26:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:01:47 2008''
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Revision as of 07:26, 3 May 2008

Image:1tvt.jpg

Template:STRUCTURE 1tvt

STRUCTURE OF THE EQUINE INFECTIOUS ANEMIA VIRUS TAT PROTEIN


Overview

Trans-activator (Tat) proteins regulate the transcription of lentiviral DNA in the host cell genome. These RNA binding proteins participate in the life cycle of all known lentiviruses, such as the human immunodeficiency viruses (HIV) or the equine infectious anemia virus (EIAV). The consensus RNA binding motifs [the trans-activation responsive element (TAR)] of HIV-1 as well as EIAV Tat proteins are well characterized. The structure of the 75-amino acid EIAV Tat protein in solution was determined by two- and three-dimensional nuclear magnetic resonance methods and molecular dynamics calculations. The protein structure exhibits a well-defined hydrophobic core of 15 amino acids that serves as a scaffold for two flexible domains corresponding to the NH2- and COOH-terminal regions. The core region is a strictly conserved sequence region among the known Tat proteins. The structural data can be used to explain several of the observed features of Tat proteins.

About this Structure

1TVT is a Single protein structure of sequence from Equine infectious anemia virus. Full crystallographic information is available from OCA.

Reference

Structure of the equine infectious anemia virus Tat protein., Willbold D, Rosin-Arbesfeld R, Sticht H, Frank R, Rosch P, Science. 1994 Jun 10;264(5165):1584-7. PMID:7515512 Page seeded by OCA on Sat May 3 10:26:00 2008

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