1tw7

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[[Image:1tw7.gif|left|200px]]
[[Image:1tw7.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1tw7 |SIZE=350|CAPTION= <scene name='initialview01'>1tw7</scene>, resolution 1.3&Aring;
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The line below this paragraph, containing "STRUCTURE_1tw7", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= HIV-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 Human immunodeficiency virus 1])
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-->
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|DOMAIN=
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{{STRUCTURE_1tw7| PDB=1tw7 | SCENE= }}
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|RELATEDENTRY=[[1rpi|1RPI]], [[1rq9|1RQ9]], [[1rv7|1RV7]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tw7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tw7 OCA], [http://www.ebi.ac.uk/pdbsum/1tw7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1tw7 RCSB]</span>
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}}
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'''Wide Open 1.3A Structure of a Multi-drug Resistant HIV-1 Protease Represents a Novel Drug Target'''
'''Wide Open 1.3A Structure of a Multi-drug Resistant HIV-1 Protease Represents a Novel Drug Target'''
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[[Category: Winters, M A.]]
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[[Category: aspartyl protease]]
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[[Category: Aspartyl protease]]
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[[Category: hiv protease]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: multi-drug resistance]]
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[[Category: Multi-drug resistance]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:26:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:02:00 2008''
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Revision as of 07:26, 3 May 2008

Image:1tw7.gif

Template:STRUCTURE 1tw7

Wide Open 1.3A Structure of a Multi-drug Resistant HIV-1 Protease Represents a Novel Drug Target


Overview

This report examines structural changes in a highly mutated, clinical multidrug-resistant HIV-1 protease, and the crystal structure has been solved to 1.3 A resolution in the absence of any inhibitor. This protease variant contains codon mutations at positions 10, 36, 46, 54, 62, 63, 71, 82, 84, and 90 that confer resistance to protease inhibitors. Major differences between the wild-type and the variant include a structural change initiated by the M36V mutation and amplified by additional mutations in the flaps of the protease, resulting in a "wide-open" structure that represents an opening that is 8 A wider than the "open" structure of the wild-type protease. A second structural change is triggered by the L90M mutation that results in reshaping the 23-32 segment. A third key structural change of the protease is due to the mutations from longer to shorter amino acid side chains at positions 82 and 84.

About this Structure

1TW7 is a Single protein structure of sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

"Wide-open" 1.3 A structure of a multidrug-resistant HIV-1 protease as a drug target., Martin P, Vickrey JF, Proteasa G, Jimenez YL, Wawrzak Z, Winters MA, Merigan TC, Kovari LC, Structure. 2005 Dec;13(12):1887-95. PMID:16338417 Page seeded by OCA on Sat May 3 10:26:45 2008

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