1tx0
From Proteopedia
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'''Dihydropteroate Synthetase, With Bound Product Analogue Pteroic Acid, From Bacillus anthracis''' | '''Dihydropteroate Synthetase, With Bound Product Analogue Pteroic Acid, From Bacillus anthracis''' | ||
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[[Category: Qi, J.]] | [[Category: Qi, J.]] | ||
[[Category: White, S W.]] | [[Category: White, S W.]] | ||
| - | [[Category: | + | [[Category: Anthracis]] |
| - | [[Category: | + | [[Category: Dihydropteroate]] |
| - | [[Category: | + | [[Category: Folate biosynthesis]] |
| - | [[Category: | + | [[Category: Pterine]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:28:22 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 07:28, 3 May 2008
Dihydropteroate Synthetase, With Bound Product Analogue Pteroic Acid, From Bacillus anthracis
Overview
Dihydropterate synthase (DHPS) is the target for the sulfonamide class of antibiotics, but increasing resistance has encouraged the development of new therapeutic agents against this enzyme. One approach is to identify molecules that occupy the pterin binding pocket which is distinct from the pABA binding pocket that binds sulfonamides. Toward this goal, we present five crystal structures of DHPS from Bacillus anthracis, a well-documented bioterrorism agent. Three DHPS structures are already known, but our B. anthracis structures provide new insights into the enzyme mechanism. We show how an arginine side chain mimics the pterin ring in binding within the pterin binding pocket. The structures of two substrate analog complexes and the first structure of a DHPS-product complex offer new insights into the catalytic mechanism and the architecture of the pABA binding pocket. Finally, as an initial step in the development of pterin-based inhibitors, we present the structure of DHPS complexed with 5-nitro-6-methylamino-isocytosine.
About this Structure
1TX0 is a Single protein structure of sequence from Bacillus anthracis str. a2012. Full crystallographic information is available from OCA.
Reference
Crystal structure of 7,8-dihydropteroate synthase from Bacillus anthracis: mechanism and novel inhibitor design., Babaoglu K, Qi J, Lee RE, White SW, Structure. 2004 Sep;12(9):1705-17. PMID:15341734 Page seeded by OCA on Sat May 3 10:28:22 2008
