2h5g
From Proteopedia
(Difference between revisions)
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<StructureSection load='2h5g' size='340' side='right'caption='[[2h5g]], [[Resolution|resolution]] 2.25Å' scene=''> | <StructureSection load='2h5g' size='340' side='right'caption='[[2h5g]], [[Resolution|resolution]] 2.25Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2h5g]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2h5g]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H5G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2H5G FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2h5g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h5g OCA], [https://pdbe.org/2h5g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2h5g RCSB], [https://www.ebi.ac.uk/pdbsum/2h5g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2h5g ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2h5g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h5g OCA], [https://pdbe.org/2h5g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2h5g RCSB], [https://www.ebi.ac.uk/pdbsum/2h5g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2h5g ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | + | [https://www.uniprot.org/uniprot/P5CS_HUMAN P5CS_HUMAN] Defects in ALDH18A1 are the cause of cutis laxa, autosomal recessive, type 3A (ARCL3A) [MIM:[https://omim.org/entry/219150 219150]. A syndrome characterized by facial dysmorphism with a progeroid appearance, large and late-closing fontanel, cutis laxa, joint hyperlaxity, athetoid movements and hyperreflexia, pre- and postnatal growth retardation, intellectual deficit, developmental delay, and ophthalmologic abnormalities.<ref>PMID:11092761</ref> <ref>PMID:18478038</ref> | |
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/P5CS_HUMAN P5CS_HUMAN] Bifunctional enzyme that converts glutamate to glutamate 5-semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine.<ref>PMID:10037775</ref> <ref>PMID:11092761</ref> | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h5/2h5g_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h5/2h5g_consurf.spt"</scriptWhenChecked> | ||
| - | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> |
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
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[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Arrowsmith | + | [[Category: Arrowsmith C]] |
| - | [[Category: Berridge | + | [[Category: Berridge G]] |
| - | [[Category: Bray | + | [[Category: Bray J]] |
| - | [[Category: Edwards | + | [[Category: Edwards A]] |
| - | [[Category: Gileadi | + | [[Category: Gileadi O]] |
| - | [[Category: Gorrec | + | [[Category: Gorrec F]] |
| - | [[Category: Hozjan | + | [[Category: Hozjan V]] |
| - | [[Category: Kavanagh | + | [[Category: Kavanagh K]] |
| - | [[Category: Oppermann | + | [[Category: Oppermann U]] |
| - | [[Category: Papagrigoriou | + | [[Category: Papagrigoriou E]] |
| - | + | [[Category: Shafqat N]] | |
| - | [[Category: Shafqat | + | [[Category: Smee C]] |
| - | [[Category: Smee | + | [[Category: Sundstrom M]] |
| - | [[Category: Sundstrom | + | [[Category: Turnbull AP]] |
| - | [[Category: Turnbull | + | [[Category: Weigelt J]] |
| - | [[Category: Weigelt | + | |
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Current revision
Crystal structure of human pyrroline-5-carboxylate synthetase
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Categories: Homo sapiens | Large Structures | Arrowsmith C | Berridge G | Bray J | Edwards A | Gileadi O | Gorrec F | Hozjan V | Kavanagh K | Oppermann U | Papagrigoriou E | Shafqat N | Smee C | Sundstrom M | Turnbull AP | Weigelt J
