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1txu

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[[Image:1txu.jpg|left|200px]]
[[Image:1txu.jpg|left|200px]]
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{{Structure
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|GENE= RABGEF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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{{STRUCTURE_1txu| PDB=1txu | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1txu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1txu OCA], [http://www.ebi.ac.uk/pdbsum/1txu PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1txu RCSB]</span>
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'''Crystal Structure of the Vps9 Domain of Rabex-5'''
'''Crystal Structure of the Vps9 Domain of Rabex-5'''
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[[Category: Lambright, D G.]]
[[Category: Lambright, D G.]]
[[Category: Merithew, E.]]
[[Category: Merithew, E.]]
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[[Category: rab5 guanine-nucleotide exchange factor,gef]]
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[[Category: Rab5 guanine-nucleotide exchange factor,gef]]
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[[Category: vps9 domain]]
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[[Category: Vps9 domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:30:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:02:36 2008''
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Revision as of 07:30, 3 May 2008

Image:1txu.jpg

Template:STRUCTURE 1txu

Crystal Structure of the Vps9 Domain of Rabex-5


Overview

The Rab5 GTPase, an essential regulator of endocytosis and endosome biogenesis, is activated by guanine-nucleotide exchange factors (GEFs) that contain a Vps9 domain. Here, we show that the catalytic core of the Rab GEF Rabex-5 has a tandem architecture consisting of a Vps9 domain stabilized by an indispensable helical bundle. A family-wide analysis of Rab specificity demonstrates high selectivity for Rab5 subfamily GTPases. Conserved exchange determinants map to a common surface of the Vps9 domain, which recognizes invariant aromatic residues in the switch regions of Rab GTPases and selects for the Rab5 subfamily by requiring a small nonacidic residue preceding a critical phenylalanine in the switch I region. These and other observations reveal unexpected similarity with the Arf exchange site in the Sec7 domain.

About this Structure

1TXU is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure, exchange determinants, and family-wide rab specificity of the tandem helical bundle and Vps9 domains of Rabex-5., Delprato A, Merithew E, Lambright DG, Cell. 2004 Sep 3;118(5):607-17. PMID:15339665 Page seeded by OCA on Sat May 3 10:30:02 2008

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