1txy

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[[Image:1txy.gif|left|200px]]
[[Image:1txy.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1txy |SIZE=350|CAPTION= <scene name='initialview01'>1txy</scene>, resolution 2.00&Aring;
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The line below this paragraph, containing "STRUCTURE_1txy", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= PRIB, B4201 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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|DOMAIN=
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{{STRUCTURE_1txy| PDB=1txy | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1txy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1txy OCA], [http://www.ebi.ac.uk/pdbsum/1txy PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1txy RCSB]</span>
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}}
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'''E. coli PriB'''
'''E. coli PriB'''
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[[Category: Keck, J L.]]
[[Category: Keck, J L.]]
[[Category: Lopper, M.]]
[[Category: Lopper, M.]]
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[[Category: dimer]]
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[[Category: Dimer]]
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[[Category: ob fold]]
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[[Category: Ob fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:30:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:02:36 2008''
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Revision as of 07:30, 3 May 2008

Template:STRUCTURE 1txy

E. coli PriB


Overview

Maintenance of genome stability following DNA damage requires origin-independent reinitiation of DNA replication at repaired replication forks. In E. coli, PriA, PriB, PriC, and DnaT play critical roles in recognizing repaired replication forks and reloading the replisome onto the template to reinitiate DNA replication. Here, we report the 2.0 A resolution crystal structure of E. coli PriB, revealing a dimer that consists of a single structural domain formed by two oligonucleotide/oligosaccharide binding (OB) folds. Structural similarity of PriB to single-stranded DNA binding proteins reveals insights into its mechanisms of DNA binding. The structure further establishes a putative protein interaction surface that may contribute to the role of PriB in primosome assembly by facilitating interactions with PriA and DnaT. This is the first high-resolution structure of a protein involved in oriC-independent replisome loading and provides unique insight into mechanisms of replication restart in E. coli.

About this Structure

1TXY is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of PriB, a component of the Escherichia coli replication restart primosome., Lopper M, Holton JM, Keck JL, Structure. 2004 Nov;12(11):1967-75. PMID:15530361 Page seeded by OCA on Sat May 3 10:30:17 2008

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