2kja

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Current revision (08:15, 30 October 2024) (edit) (undo)
 
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==Chemical shift assignments, constraints, and coordinates for CN5 scorpion toxin==
==Chemical shift assignments, constraints, and coordinates for CN5 scorpion toxin==
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<StructureSection load='2kja' size='340' side='right'caption='[[2kja]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
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<StructureSection load='2kja' size='340' side='right'caption='[[2kja]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2kja]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Centruroides_noxius Centruroides noxius]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KJA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KJA FirstGlance]. <br>
<table><tr><td colspan='2'>[[2kja]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Centruroides_noxius Centruroides noxius]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KJA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KJA FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kja OCA], [https://pdbe.org/2kja PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kja RCSB], [https://www.ebi.ac.uk/pdbsum/2kja PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kja ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 15 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kja OCA], [https://pdbe.org/2kja PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kja RCSB], [https://www.ebi.ac.uk/pdbsum/2kja PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kja ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/SCX5_CENNO SCX5_CENNO]] Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing. This toxin is lethal to crustaceans (freshwater crayfish (Cambarellus montezumae spp.)), it provokes a reversible paralysis to insects (crickets (Achaeta spp.)), but is not toxic to mice. At high concentrations, it does displace the (beta) mammal-specific toxin Cn2 from rat brain synaptosomes.<ref>PMID:19631296</ref>
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[https://www.uniprot.org/uniprot/SCX5_CENNO SCX5_CENNO] Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing. This toxin is lethal to crustaceans (freshwater crayfish (Cambarellus montezumae spp.)), it provokes a reversible paralysis to insects (crickets (Achaeta spp.)), but is not toxic to mice. At high concentrations, it does displace the (beta) mammal-specific toxin Cn2 from rat brain synaptosomes.<ref>PMID:19631296</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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<jmolCheckbox>
<jmolCheckbox>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kj/2kja_consurf.spt"</scriptWhenChecked>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kj/2kja_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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[[Category: Centruroides noxius]]
[[Category: Centruroides noxius]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Corzo, G]]
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[[Category: Corzo G]]
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[[Category: Delepierre, M]]
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[[Category: Delepierre M]]
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[[Category: Garcia, B I]]
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[[Category: Garcia BI]]
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[[Category: Possani, L D]]
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[[Category: Possani LD]]
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[[Category: Prochnicka-Chalufour, A]]
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[[Category: Prochnicka-Chalufour A]]
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[[Category: Centruroides suffusus suffusus]]
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[[Category: Disulfide bond]]
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[[Category: Ionic channel inhibitor]]
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[[Category: Na +channel inhibitor]]
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[[Category: Neurotoxin]]
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[[Category: Nmr solution structure]]
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[[Category: Scorpion toxin]]
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[[Category: Secreted]]
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[[Category: Sodium channel inhibitor]]
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[[Category: Toxin]]
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Current revision

Chemical shift assignments, constraints, and coordinates for CN5 scorpion toxin

PDB ID 2kja

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