2kjx

From Proteopedia

(Difference between revisions)

Current revision

Solution structure of the extracellular domain of JTB

Structural highlights

2kjx is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Solution NMR, 20 models
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

JTB_HUMAN Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity).^[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Jumping Translocation Breakpoint (JTB) is an orphan receptor that is conserved from nematodes to humans and whose gene expression in humans is strikingly upregulated in diverse types of cancers. Translocations occur frequently at the hJTB genomic locus, leading to multiple copies of a truncated JTB gene, which potentially encodes a soluble secreted ectodomain. In addition, JTB and its orthologs likely represent a unique and ancient protein family since homologs could not be identified by direct sequence comparison. In the present study, we have determined the NMR solution structure of the N-terminal ectodomain of human JTB, showing that its fold architecture is a new variant of a three-beta-strand antiparallel beta-meander. The JTB structure has a distant relationship to the midkine/pleiotrophin fold, particularly in the conservation of distinctive disulfide bridge patterns. The structure of this newly characterized small cysteine-rich domain suggests potential involvement of JTB in interactions with proteins or extracellular matrix and may help to uncover the elusive biological functions of this protein.

The Structure of the Extracellular Domain of the Jumping Translocation Breakpoint Protein Reveals a Variation of the Midkine Fold.,Rousseau F, Pan B, Fairbrother WJ, Bazan JF, Lingel A J Mol Biol. 2011 Nov 4. PMID:22079049^[2]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Platica M, Ionescu A, Ivan E, Holland JF, Mandeli J, Platica O. PAR, a protein involved in the cell cycle, is functionally related to chromosomal passenger proteins. Int J Oncol. 2011 Mar;38(3):777-85. doi: 10.3892/ijo.2011.900. Epub 2011 Jan 11. PMID:21225229 doi:http://dx.doi.org/10.3892/ijo.2011.900
↑ Rousseau F, Pan B, Fairbrother WJ, Bazan JF, Lingel A. The Structure of the Extracellular Domain of the Jumping Translocation Breakpoint Protein Reveals a Variation of the Midkine Fold. J Mol Biol. 2011 Nov 4. PMID:22079049 doi:10.1016/j.jmb.2011.10.048

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2kjx"

@@ Line 1: / Line 1: @@
 ==Solution structure of the extracellular domain of JTB==
-<StructureSection load='2kjx' size='340' side='right'caption='[[2kjx]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+<StructureSection load='2kjx' size='340' side='right'caption='[[2kjx]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2kjx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KJX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KJX FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2kjx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KJX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KJX FirstGlance]. <br>
-</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">JTB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kjx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kjx OCA], [https://pdbe.org/2kjx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kjx RCSB], [https://www.ebi.ac.uk/pdbsum/2kjx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kjx ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[https://www.uniprot.org/uniprot/JTB_HUMAN JTB_HUMAN]] Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity).<ref>PMID:21225229</ref>
+[https://www.uniprot.org/uniprot/JTB_HUMAN JTB_HUMAN] Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity).<ref>PMID:21225229</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 14: / Line 14: @@
   <jmolCheckbox>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kj/2kjx_consurf.spt"</scriptWhenChecked>
-    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
@@ Line 32: / Line 32: @@
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Bazan, F]]
+[[Category: Bazan F]]
-[[Category: Fairbrother, W J]]
+[[Category: Fairbrother WJ]]
-[[Category: Lingel, A]]
+[[Category: Lingel A]]
-[[Category: Pan, B]]
+[[Category: Pan B]]
-[[Category: Rousseau, F]]
+[[Category: Rousseau F]]
-[[Category: Cysteine-rich domain]]
-[[Category: Membrane]]
-[[Category: Membrane protein]]
-[[Category: Transmembrane]]

2kjx

From Proteopedia

Current revision

Solution structure of the extracellular domain of JTB

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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