2zec
From Proteopedia
(Difference between revisions)
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<StructureSection load='2zec' size='340' side='right'caption='[[2zec]], [[Resolution|resolution]] 2.06Å' scene=''> | <StructureSection load='2zec' size='340' side='right'caption='[[2zec]], [[Resolution|resolution]] 2.06Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2zec]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2zec]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZEC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZEC FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.059Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=11N:1-[1-(3-PHENYLACRYLOYL)SPIRO[1-BENZOFURAN-3,4-PIPERIDIN]-5-YL]METHANAMINE'>11N</scene></td></tr> |
| - | + | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zec FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zec OCA], [https://pdbe.org/2zec PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zec RCSB], [https://www.ebi.ac.uk/pdbsum/2zec PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zec ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zec FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zec OCA], [https://pdbe.org/2zec PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zec RCSB], [https://www.ebi.ac.uk/pdbsum/2zec PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zec ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/TRYB1_HUMAN TRYB1_HUMAN] Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type (By similarity). | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ze/2zec_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ze/2zec_consurf.spt"</scriptWhenChecked> | ||
| - | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> |
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Lewandowski | + | [[Category: Lewandowski F]] |
| - | [[Category: Milligan | + | [[Category: Milligan C]] |
| - | [[Category: Spurlino | + | [[Category: Spurlino JC]] |
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Current revision
Potent, Nonpeptide Inhibitors of Human Mast Cell Tryptase
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