3c8p

From Proteopedia

(Difference between revisions)

Current revision

X-ray structure of Viscotoxin A1 from Viscum album L.

Structural highlights

3c8p is a 2 chain structure with sequence from Viscum album. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.25Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

D0VWT3_VISAL

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Crystals of the cytotoxic thionin proteins viscotoxins A1 and B2 extracted from mistletoe diffracted to high resolution (1.25 and 1.05 A, respectively) and are excellent candidates for testing crystallographic methods. Ab initio direct methods were only successful in solving the viscotoxin B2 structure, which with 861 unique non-H atoms is one of the largest unknown structures without an atom heavier than sulfur to be solved in this way, but sulfur-SAD phasing provided a convincing solution for viscotoxin A1. Both proteins form dimers in the crystal and viscotoxin B2 (net charge +4 per monomer), but not viscotoxin A1 (net charge +6), is coordinated by sulfate or phosphate anions. The viscotoxin A1 crystal has a higher solvent content than the viscotoxin B2 crystal (49% as opposed to 28%) with solvent channels along the crystallographic 4(3) axes.

Structures of viscotoxins A1 and B2 from European mistletoe solved using native data alone.,Pal A, Debreczeni JE, Sevvana M, Gruene T, Kahle B, Zeeck A, Sheldrick GM Acta Crystallogr D Biol Crystallogr. 2008 Sep;64(Pt 9):985-92. Epub 2008, Aug 13. PMID:18703848^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Pal A, Debreczeni JE, Sevvana M, Gruene T, Kahle B, Zeeck A, Sheldrick GM. Structures of viscotoxins A1 and B2 from European mistletoe solved using native data alone. Acta Crystallogr D Biol Crystallogr. 2008 Sep;64(Pt 9):985-92. Epub 2008, Aug 13. PMID:18703848 doi:10.1107/S0907444908022646

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3c8p"

@@ Line 3: / Line 3: @@
 <StructureSection load='3c8p' size='340' side='right'caption='[[3c8p]], [[Resolution|resolution]] 1.25&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3c8p]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Viscum_album Viscum album]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C8P OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3C8P FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3c8p]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Viscum_album Viscum album]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C8P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C8P FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3c8p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c8p OCA], [http://pdbe.org/3c8p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3c8p RCSB], [http://www.ebi.ac.uk/pdbsum/3c8p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3c8p ProSAT]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.25&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c8p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c8p OCA], [https://pdbe.org/3c8p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c8p RCSB], [https://www.ebi.ac.uk/pdbsum/3c8p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c8p ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/D0VWT3_VISAL D0VWT3_VISAL]
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 11: / Line 14: @@
   <jmolCheckbox>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c8/3c8p_consurf.spt"</scriptWhenChecked>
-    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
@@ Line 31: / Line 34: @@
 [[Category: Large Structures]]
 [[Category: Viscum album]]
-[[Category: Debreczeni, J E]]
+[[Category: Debreczeni JE]]
-[[Category: Gruene, T]]
+[[Category: Gruene T]]
-[[Category: Kahle, B]]
+[[Category: Kahle B]]
-[[Category: Pal, A]]
+[[Category: Pal A]]
-[[Category: Sevvana, M]]
+[[Category: Sevvana M]]
-[[Category: Sheldrick, G M]]
+[[Category: Sheldrick GM]]
-[[Category: Zeeck, A]]
+[[Category: Zeeck A]]
-[[Category: Helix turn helix]]
-[[Category: Toxin]]

3c8p

From Proteopedia

Current revision

X-ray structure of Viscotoxin A1 from Viscum album L.

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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