1tyx

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[[Image:1tyx.gif|left|200px]]
[[Image:1tyx.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1tyx |SIZE=350|CAPTION= <scene name='initialview01'>1tyx</scene>, resolution 1.8&Aring;
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The line below this paragraph, containing "STRUCTURE_1tyx", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ABE:ABEQUOSE'>ABE</scene>, <scene name='pdbligand=GLA:ALPHA+D-GALACTOSE'>GLA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=RAM:RHAMNOSE'>RAM</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= PHAGE P22 GENE 9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id= SALMONELLA TYPHIMURIUM PHAGE P22])
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-->
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|DOMAIN=
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{{STRUCTURE_1tyx| PDB=1tyx | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tyx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tyx OCA], [http://www.ebi.ac.uk/pdbsum/1tyx PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1tyx RCSB]</span>
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}}
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'''TITLE OF TAILSPIKE-PROTEIN'''
'''TITLE OF TAILSPIKE-PROTEIN'''
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[[Category: Huber, R.]]
[[Category: Huber, R.]]
[[Category: Steinbacher, S.]]
[[Category: Steinbacher, S.]]
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[[Category: binding protein lipopolysaccharide]]
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[[Category: Binding protein lipopolysaccharide]]
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[[Category: cell receptor]]
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[[Category: Cell receptor]]
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[[Category: complex]]
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[[Category: Complex]]
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[[Category: endoglycosidase carbohydrate]]
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[[Category: Endoglycosidase carbohydrate]]
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[[Category: receptor]]
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[[Category: Receptor]]
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[[Category: recognition]]
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[[Category: Recognition]]
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[[Category: viral adhesion protein]]
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[[Category: Viral adhesion protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:32:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:03:03 2008''
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Revision as of 07:32, 3 May 2008

Image:1tyx.gif

Template:STRUCTURE 1tyx

TITLE OF TAILSPIKE-PROTEIN


Overview

The O-antigenic repeating units of lipopolysaccharides from Salmonella serogroups A, B, and D1 serve as receptors for the phage P22 tailspike protein, which also has receptor destroying endoglycosidase (endorhamnosidase) activity, integrating the functions of both hemagglutinin and neuraminidase in influenza virus. Crystal structures of the tailspike protein in complex with oligosaccharides, comprising two O-antigenic repeating units from Salmonella typhimurium, Salmonella enteritidis, and Salmonella typhi 253Ty were determined at 1.8 A resolution. The active-site topology with Asp-392, Asp-395, and Glu-359 as catalytic residues was identified. Kinetics of binding and cleavage suggest a role of the receptor destroying endorhamnosidase activity primarily for detachment of newly assembled phages.

About this Structure

1TYX is a Single protein structure of sequence from Salmonella typhimurium phage p22. Full crystallographic information is available from OCA.

Reference

Crystal structure of phage P22 tailspike protein complexed with Salmonella sp. O-antigen receptors., Steinbacher S, Baxa U, Miller S, Weintraub A, Seckler R, Huber R, Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):10584-8. PMID:8855221 Page seeded by OCA on Sat May 3 10:32:12 2008

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OCA

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