3g5t

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:10, 30 October 2024) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='3g5t' size='340' side='right'caption='[[3g5t]], [[Resolution|resolution]] 1.12&Aring;' scene=''>
<StructureSection load='3g5t' size='340' side='right'caption='[[3g5t]], [[Resolution|resolution]] 1.12&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[3g5t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G5T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G5T FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[3g5t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G5T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G5T FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=T8N:(2E)-2-(2-METHOXY-2-OXOETHYL)BUT-2-ENEDIOIC+ACID'>T8N</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.119&#8491;</td></tr>
-
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=T8N:(2E)-2-(2-METHOXY-2-OXOETHYL)BUT-2-ENEDIOIC+ACID'>T8N</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">P32643, S000000977, SYGP-ORF63, TAM1, TMT1, YER175C ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
+
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Trans-aconitate_3-methyltransferase Trans-aconitate 3-methyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.145 2.1.1.145] </span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g5t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g5t OCA], [https://pdbe.org/3g5t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g5t RCSB], [https://www.ebi.ac.uk/pdbsum/3g5t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g5t ProSAT], [https://www.topsan.org/Proteins/CESG/3g5t TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g5t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g5t OCA], [https://pdbe.org/3g5t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g5t RCSB], [https://www.ebi.ac.uk/pdbsum/3g5t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g5t ProSAT], [https://www.topsan.org/Proteins/CESG/3g5t TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[https://www.uniprot.org/uniprot/TMT1_YEAST TMT1_YEAST]] Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate and 3-isopropylmalate at high affinity and of other molecules like cis-aconitate, isocitrate, and citrate at lower velocities and affinities. The function of trans-aconitate methylation appears to be in reducing the toxicity of this spontaneous breakdown product of cis-aconitate. The role of 3-isopropylmalate methylation is unclear but may represent a metabolic branch at 3-isopropylmalate, where some of the material is taken in the pathway leading to leucine and some is taken in a pathway to the 3-isopropylmalate methyl ester, a molecule that provides a signal to switch from vegetative to invasive growth in response to amino acid starvation.<ref>PMID:11695919</ref> <ref>PMID:15147181</ref> <ref>PMID:18092814</ref>
+
[https://www.uniprot.org/uniprot/TMT1_YEAST TMT1_YEAST] Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate and 3-isopropylmalate at high affinity and of other molecules like cis-aconitate, isocitrate, and citrate at lower velocities and affinities. The function of trans-aconitate methylation appears to be in reducing the toxicity of this spontaneous breakdown product of cis-aconitate. The role of 3-isopropylmalate methylation is unclear but may represent a metabolic branch at 3-isopropylmalate, where some of the material is taken in the pathway leading to leucine and some is taken in a pathway to the 3-isopropylmalate methyl ester, a molecule that provides a signal to switch from vegetative to invasive growth in response to amino acid starvation.<ref>PMID:11695919</ref> <ref>PMID:15147181</ref> <ref>PMID:18092814</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 17: Line 15:
<jmolCheckbox>
<jmolCheckbox>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g5/3g5t_consurf.spt"</scriptWhenChecked>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g5/3g5t_consurf.spt"</scriptWhenChecked>
-
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
Line 26: Line 24:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Atcc 18824]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Trans-aconitate 3-methyltransferase]]
+
[[Category: Saccharomyces cerevisiae]]
-
[[Category: Bingman, C A]]
+
[[Category: Bingman CA]]
-
[[Category: Burgie, E S]]
+
[[Category: Burgie ES]]
-
[[Category: Structural genomic]]
+
[[Category: Phillips Jr GN]]
-
[[Category: Phillips, G N]]
+
[[Category: Wesenberg GE]]
-
[[Category: Wesenberg, G E]]
+
-
[[Category: Cesg]]
+
-
[[Category: Cytoplasm]]
+
-
[[Category: Methyltransferase]]
+
-
[[Category: Phosphoprotein]]
+
-
[[Category: PSI, Protein structure initiative]]
+
-
[[Category: S-adenosyl-l-methionine]]
+
-
[[Category: Transferase]]
+

Current revision

Crystal structure of trans-aconitate 3-methyltransferase from yeast

PDB ID 3g5t

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3g5t"
Personal tools