3hh7

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Current revision (09:14, 30 October 2024) (edit) (undo)
 
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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3hh7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ophiophagus_hannah Ophiophagus hannah]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HH7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HH7 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3hh7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ophiophagus_hannah Ophiophagus hannah]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HH7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HH7 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hh7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hh7 OCA], [https://pdbe.org/3hh7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hh7 RCSB], [https://www.ebi.ac.uk/pdbsum/3hh7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hh7 ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hh7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hh7 OCA], [https://pdbe.org/3hh7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hh7 RCSB], [https://www.ebi.ac.uk/pdbsum/3hh7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hh7 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/TML3H_OPHHA TML3H_OPHHA]] Antagonist of muscle and neuronal nicotinic acetylcholine receptors (nAChR) with highest affinity for alpha(7)-nAChRs.<ref>PMID:20071329</ref>
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[https://www.uniprot.org/uniprot/3SO8_OPHHA 3SO8_OPHHA] Antagonist of muscle (alpha-1-beta-1-delta-epsilon/CHRNA1-CHRNB1-CHRND-CHRNE) and neuronal (alpha-7/CHRNA7, alpha-3-beta-2/CHRNA3-CHRNB2, alpha-4-beta-2/CHRNA4-CHRNB2) nicotinic acetylcholine receptors (nAChR) (PubMed:20071329). The highest affinity is for human alpha-7/CHRNA7 nAChRs (IC(50)=180 nM), compared to human alpha-1-beta-1-delta-epsilon/CHRNA1-CHRNB1-CHRND-CHRNE nAChR (IC(50)= 550 nM), alpha-3-beta-2/CHRNA3-CHRNB2 nAChR (IC(50)=500 nM), and alpha-4-beta-2/CHRNA4-CHRNB2 nAChR (IC(50)=2.6 uM).<ref>PMID:20071329</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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<jmolCheckbox>
<jmolCheckbox>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hh/3hh7_consurf.spt"</scriptWhenChecked>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hh/3hh7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Ophiophagus hannah]]
[[Category: Ophiophagus hannah]]
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[[Category: Bertrand, D]]
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[[Category: Bertrand D]]
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[[Category: Chong, M Z]]
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[[Category: Chong MZ]]
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[[Category: Foo, C S]]
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[[Category: D'hoedt D]]
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[[Category: Kini, R M]]
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[[Category: Foo CS]]
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[[Category: Nirthanan, S]]
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[[Category: Kini RM]]
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[[Category: Rajagopalan, N]]
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[[Category: Nirthanan S]]
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[[Category: Roy, A]]
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[[Category: Rajagopalan N]]
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[[Category: Sivaraman, J]]
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[[Category: Roy A]]
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[[Category: Zhou, X]]
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[[Category: Sivaraman J]]
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[[Category: Hoedt, D D]]
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[[Category: Zhou X]]
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[[Category: Acetylcholine receptor inhibitor]]
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[[Category: Disulfide bond]]
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[[Category: Haditoxin]]
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[[Category: Neurotoxin]]
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[[Category: Nicotinic acetylcholine receptor]]
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[[Category: Postsynaptic neurotoxin]]
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[[Category: Secreted]]
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[[Category: Snake venom]]
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[[Category: Three finger toxin]]
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[[Category: Toxin]]
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Current revision

Structural and Functional Characterization of a Novel Homodimeric Three-finger Neurotoxin from the Venom of Ophiophagus hannah (King Cobra)

PDB ID 3hh7

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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