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| | <StructureSection load='3ix0' size='340' side='right'caption='[[3ix0]], [[Resolution|resolution]] 2.30Å' scene=''> | | <StructureSection load='3ix0' size='340' side='right'caption='[[3ix0]], [[Resolution|resolution]] 2.30Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[3ix0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IX0 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3IX0 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[3ix0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IX0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IX0 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3ix0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ix0 OCA], [http://pdbe.org/3ix0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ix0 RCSB], [http://www.ebi.ac.uk/pdbsum/3ix0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ix0 ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> |
| | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ix0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ix0 OCA], [https://pdbe.org/3ix0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ix0 RCSB], [https://www.ebi.ac.uk/pdbsum/3ix0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ix0 ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | == Disease == | | == Disease == |
| - | [[http://www.uniprot.org/uniprot/MSMB_HUMAN MSMB_HUMAN]] Defects in MSMB are the cause of susceptibility to prostate cancer hereditary type 13 (HPC13) [MIM:[http://omim.org/entry/611928 611928]]. It is a condition associated with familial predisposition to cancer of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. | + | [https://www.uniprot.org/uniprot/MSMB_HUMAN MSMB_HUMAN] Defects in MSMB are the cause of susceptibility to prostate cancer hereditary type 13 (HPC13) [MIM:[https://omim.org/entry/611928 611928]. It is a condition associated with familial predisposition to cancer of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. |
| | + | == Function == |
| | + | [https://www.uniprot.org/uniprot/MSMB_HUMAN MSMB_HUMAN] |
| | == Evolutionary Conservation == | | == Evolutionary Conservation == |
| | [[Image:Consurf_key_small.gif|200px|right]] | | [[Image:Consurf_key_small.gif|200px|right]] |
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| | <jmolCheckbox> | | <jmolCheckbox> |
| | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ix/3ix0_consurf.spt"</scriptWhenChecked> | | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ix/3ix0_consurf.spt"</scriptWhenChecked> |
| - | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> |
| | <text>to colour the structure by Evolutionary Conservation</text> | | <text>to colour the structure by Evolutionary Conservation</text> |
| | </jmolCheckbox> | | </jmolCheckbox> |
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| | [[Category: Homo sapiens]] | | [[Category: Homo sapiens]] |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Jagtap, D D]] | + | [[Category: Jagtap DD]] |
| - | [[Category: Kumar, A]] | + | [[Category: Kumar A]] |
| - | [[Category: Kumar, M]] | + | [[Category: Kumar M]] |
| - | [[Category: Mahale, S D]] | + | [[Category: Mahale SD]] |
| - | [[Category: Antitumor protein]]
| + | |
| - | [[Category: Apoptosis]]
| + | |
| - | [[Category: Beta sheet]]
| + | |
| - | [[Category: Disulfide bond]]
| + | |
| - | [[Category: Greek key motif]]
| + | |
| - | [[Category: Protein binding]]
| + | |
| - | [[Category: Secreted]]
| + | |
| Structural highlights
Disease
MSMB_HUMAN Defects in MSMB are the cause of susceptibility to prostate cancer hereditary type 13 (HPC13) [MIM:611928. It is a condition associated with familial predisposition to cancer of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma.
Function
MSMB_HUMAN
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
Several recent genome-wide association studies have linked the human MSMB gene, encoding prostate secretory protein of 94 residues (PSP94), with prostate cancer susceptibility. PSP94 is one of the most abundant proteins from prostatic secretions and a primary constituent of human semen. PSP94 suppresses tumor growth and metastasis, and its expression gradually decreases during progression of the prostate cancer. It is a rapidly evolving protein with homologues present in several species with 10 conserved cysteine residues. PSP94 homologues show high-affinity binding with different proteins from the cysteine-rich secretory protein family, some of which have been shown to be ion channel blockers. Here, we report the crystal structure of human PSP94 at 2.3 A resolution. The structure shows that the amino and the carboxyl ends of the polypeptide chain are held in close proximity facing each other. A strong hydrogen bond between these ends, which are located respectively on the first and the last beta-strands, leads to formation of an almost straight edge in PSP94 structure. Crystal structure shows that these edges from two PSP94 monomers associate in antiparallel fashion, leading to formation of a dimer. Our studies further show that dimers dissociate into monomers at acidic pH, possibly through distortion of the straight edge. Further, based on several observations, we propose that PSP94 binds to cysteine-rich secretory proteins and immunoglobulin G through the same edge, which is involved in the formation of PSP94 dimeric interface.
Crystal structure of prostate secretory protein PSP94 shows an edge-to-edge association of two monomers to form a homodimer.,Kumar A, Jagtap DD, Mahale SD, Kumar M J Mol Biol. 2010 Apr 9;397(4):947-56. Epub 2010 Feb 23. PMID:20184897[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Kumar A, Jagtap DD, Mahale SD, Kumar M. Crystal structure of prostate secretory protein PSP94 shows an edge-to-edge association of two monomers to form a homodimer. J Mol Biol. 2010 Apr 9;397(4):947-56. Epub 2010 Feb 23. PMID:20184897 doi:10.1016/j.jmb.2010.02.035
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