3u8h

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Current revision (09:44, 30 October 2024) (edit) (undo)
 
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<StructureSection load='3u8h' size='340' side='right'caption='[[3u8h]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='3u8h' size='340' side='right'caption='[[3u8h]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3u8h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U8H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U8H FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3u8h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U8H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U8H FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BHP:(S)-5-(4-BENZYLOXY-PHENYL)-4-(7-PHENYL-HEPTANOYLAMINO)-PENTANOIC+ACID'>BHP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3u8b|3u8b]], [[3u8d|3u8d]], [[3u8i|3u8i]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BHP:(S)-5-(4-BENZYLOXY-PHENYL)-4-(7-PHENYL-HEPTANOYLAMINO)-PENTANOIC+ACID'>BHP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PLA2G2A, PLA2B, PLA2L, RASF-A ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u8h OCA], [https://pdbe.org/3u8h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u8h RCSB], [https://www.ebi.ac.uk/pdbsum/3u8h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u8h ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u8h OCA], [https://pdbe.org/3u8h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u8h RCSB], [https://www.ebi.ac.uk/pdbsum/3u8h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u8h ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/PA2GA_HUMAN PA2GA_HUMAN]] Thought to participate in the regulation of the phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
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[https://www.uniprot.org/uniprot/PA2GA_HUMAN PA2GA_HUMAN] Thought to participate in the regulation of the phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bouveret, R]]
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[[Category: Bouveret R]]
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[[Category: Bryant, K J]]
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[[Category: Bryant KJ]]
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[[Category: Church, W B]]
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[[Category: Church WB]]
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[[Category: Cunningham, A M]]
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[[Category: Cunningham AM]]
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[[Category: Curmi, P M]]
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[[Category: Curmi PM]]
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[[Category: Duff, A P]]
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[[Category: Duff AP]]
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[[Category: Gelb, M H]]
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[[Category: Gelb MH]]
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[[Category: Gray, P P]]
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[[Category: Gray PP]]
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[[Category: Harrop, S J]]
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[[Category: Harrop SJ]]
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[[Category: Harvey, R P]]
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[[Category: Harvey RP]]
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[[Category: Huang, E P]]
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[[Category: Huang EP]]
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[[Category: Lee, L K]]
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[[Category: Lee LK]]
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[[Category: Lei, P W]]
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[[Category: Lei P-W]]
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[[Category: Scott, K F]]
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[[Category: Scott KF]]
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[[Category: Hydrolase]]
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[[Category: Phospholipase a2 activity]]
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[[Category: Secreted phospholipase a2]]
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Current revision

Functionally selective inhibition of Group IIA phospholipase A2 reveals a role for vimentin in regulating arachidonic acid metabolism

PDB ID 3u8h

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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