3vae
From Proteopedia
(Difference between revisions)
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<StructureSection load='3vae' size='340' side='right'caption='[[3vae]], [[Resolution|resolution]] 2.80Å' scene=''> | <StructureSection load='3vae' size='340' side='right'caption='[[3vae]], [[Resolution|resolution]] 2.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3vae]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3vae]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VAE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VAE FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> |
| - | + | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vae FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vae OCA], [https://pdbe.org/3vae PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vae RCSB], [https://www.ebi.ac.uk/pdbsum/3vae PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vae ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vae FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vae OCA], [https://pdbe.org/3vae PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vae RCSB], [https://www.ebi.ac.uk/pdbsum/3vae PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vae ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/LDT2_MYCTO LDT2_MYCTO] Generates 3->3 cross-links in peptidoglycan, catalyzing the cleavage of the mDap(3)-D-Ala(4) bond of a tetrapeptide donor stem and the formation of a bond between the carbonyl of mDap(3) of the donor stem and the side chain of mDap(3) of the acceptor stem. Is specific for donor substrates containing a stem tetrapeptide since it cannot use pentapeptide stems. Is essential for virulence in a mouse model of acute infection.<ref>PMID:20305661</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Amzel | + | [[Category: Mycobacterium tuberculosis]] |
| - | [[Category: Bianchet | + | [[Category: Amzel LM]] |
| - | [[Category: Erdemli | + | [[Category: Bianchet MA]] |
| - | [[Category: Gupta | + | [[Category: Erdemli S]] |
| - | [[Category: Lamichhane | + | [[Category: Gupta R]] |
| - | + | [[Category: Lamichhane G]] | |
| - | + | ||
Current revision
Crystal Structure of M. tuberculosis LD-transpeptidase type 2 with Modified Catalytic Cysteine (C354)
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