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1u0l
From Proteopedia
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'''Crystal structure of YjeQ from Thermotoga maritima''' | '''Crystal structure of YjeQ from Thermotoga maritima''' | ||
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[[Category: Shin, D H.]] | [[Category: Shin, D H.]] | ||
[[Category: Yokota, H.]] | [[Category: Yokota, H.]] | ||
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| - | [[Category: | + | [[Category: Bsgc structure funded by nih]] |
| - | [[Category: | + | [[Category: Gtpase]] |
| - | [[Category: | + | [[Category: Ob-fold]] |
| - | [[Category: | + | [[Category: Permutation]] |
| - | [[Category: | + | [[Category: Protein structure initiative]] |
| - | [[Category: | + | [[Category: Psi]] |
| - | [[Category: | + | [[Category: Structural genomic]] |
| - | [[Category: | + | [[Category: Zinc-finger]] |
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Revision as of 07:36, 3 May 2008
Crystal structure of YjeQ from Thermotoga maritima
Overview
We have determined the crystal structure of the GDP complex of the YjeQ protein from Thermotoga maritima (TmYjeQ), a member of the YjeQ GTPase subfamaily. TmYjeQ, a homologue of Escherichia coli YjeQ, which is known to bind to the ribosome, is composed of three domains: an N-terminal oligonucleotide/oligosaccharide-binding fold domain, a central GTPase domain, and a C-terminal zinc-finger domain. The crystal structure of TmYjeQ reveals two interesting domains: a circularly permutated GTPase domain and an unusual zinc-finger domain. The binding mode of GDP in the GTPase domain of TmYjeQ is similar to those of GDP or GTP analogs in ras proteins, a prototype GTPase. The N-terminal oligonucleotide/oligosaccharide-binding fold domain, together with the GTPase domain, forms the extended RNA-binding site. The C-terminal domain has an unusual zinc-finger motif composed of Cys-250, Cys-255, Cys-263, and His-257, with a remote structural similarity to a portion of a DNA-repair protein, rad51 fragment. The overall structural features of TmYjeQ make it a good candidate for an RNA-binding protein, which is consistent with the biochemical data of the YjeQ subfamily in binding to the ribosome.
About this Structure
1U0L is a Single protein structure of sequence from Thermotoga maritima. Full crystallographic information is available from OCA.
Reference
Crystal structure of YjeQ from Thermotoga maritima contains a circularly permuted GTPase domain., Shin DH, Lou Y, Jancarik J, Yokota H, Kim R, Kim SH, Proc Natl Acad Sci U S A. 2004 Sep 7;101(36):13198-203. Epub 2004 Aug 26. PMID:15331784 Page seeded by OCA on Sat May 3 10:36:09 2008
Categories: Single protein | Thermotoga maritima | BSGC, Berkeley Structural Genomics Center. | Jaru, J. | Kim, R. | Kim, S H. | Lou, Y. | Shin, D H. | Yokota, H. | Berkeley structural genomics center | Bsgc structure funded by nih | Gtpase | Ob-fold | Permutation | Protein structure initiative | Psi | Structural genomic | Zinc-finger
