6c3r

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Current revision (11:04, 30 October 2024) (edit) (undo)
 
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<StructureSection load='6c3r' size='340' side='right'caption='[[6c3r]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='6c3r' size='340' side='right'caption='[[6c3r]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6c3r]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Crpvc Crpvc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C3R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C3R FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6c3r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Cricket_paralysis_virus_Teleogryllus_commodus/Australia/CrPVVIC/1968 Cricket paralysis virus Teleogryllus commodus/Australia/CrPVVIC/1968]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C3R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6C3R FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ORF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=928300 CRPVC])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6c3r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c3r OCA], [http://pdbe.org/6c3r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6c3r RCSB], [http://www.ebi.ac.uk/pdbsum/6c3r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6c3r ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6c3r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c3r OCA], [https://pdbe.org/6c3r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6c3r RCSB], [https://www.ebi.ac.uk/pdbsum/6c3r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6c3r ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/POLN_CRPVC POLN_CRPVC]] Protein 1A functions as a suppressor of RNA-mediated gene silencing, an antiviral defense mechanism of insect cells. Inhibits siRNA function, but does not interfere with miRNA pathway. Does not bind to dsRNA or siRNA.<ref>PMID:20400949</ref> RNA-directed RNA polymerase replicates genomic and antigenomic RNA.[PROSITE-ProRule:PRU00539]<ref>PMID:20400949</ref>
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[https://www.uniprot.org/uniprot/POLN_CRPVC POLN_CRPVC] Protein 1A functions as a suppressor of RNA-mediated gene silencing, an antiviral defense mechanism of insect cells. Inhibits siRNA function, but does not interfere with miRNA pathway. Does not bind to dsRNA or siRNA.<ref>PMID:20400949</ref> RNA-directed RNA polymerase replicates genomic and antigenomic RNA.[PROSITE-ProRule:PRU00539]<ref>PMID:20400949</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Crpvc]]
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[[Category: Cricket paralysis virus Teleogryllus commodus/Australia/CrPVVIC/1968]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Andino, R]]
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[[Category: Andino R]]
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[[Category: Gross, J]]
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[[Category: Gross J]]
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[[Category: Kim, D Y]]
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[[Category: Kim DY]]
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[[Category: Nayak, A]]
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[[Category: Nayak A]]
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[[Category: Rnai inhibitor]]
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[[Category: Viral protein]]
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Current revision

Cricket paralysis virus RNAi suppressor protein CrPV-1A

PDB ID 6c3r

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