6lxw

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Current revision (11:11, 30 October 2024) (edit) (undo)
 
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<StructureSection load='6lxw' size='340' side='right'caption='[[6lxw]], [[Resolution|resolution]] 3.27&Aring;' scene=''>
<StructureSection load='6lxw' size='340' side='right'caption='[[6lxw]], [[Resolution|resolution]] 3.27&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6lxw]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/"diplococcus_pneumoniae"_(klein_1884)_weichselbaum_1886 "diplococcus pneumoniae" (klein 1884) weichselbaum 1886] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LXW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6LXW FirstGlance]. <br>
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LXW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LXW FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IGHA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), JCHAIN, IGCJ, IGJ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), PIGR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), spsA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 "Diplococcus pneumoniae" (Klein 1884) Weichselbaum 1886])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.27&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6lxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lxw OCA], [http://pdbe.org/6lxw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6lxw RCSB], [http://www.ebi.ac.uk/pdbsum/6lxw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6lxw ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lxw OCA], [https://pdbe.org/6lxw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lxw RCSB], [https://www.ebi.ac.uk/pdbsum/6lxw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lxw ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
 
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[[http://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN]] Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.
 
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== Function ==
 
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[[http://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN]] Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells. [[http://www.uniprot.org/uniprot/PIGR_HUMAN PIGR_HUMAN]] This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment. [[http://www.uniprot.org/uniprot/IGJ_HUMAN IGJ_HUMAN]] Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.[UniProtKB:P01592]
 
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Li, Y]]
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[[Category: Li Y]]
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[[Category: Wang, G]]
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[[Category: Wang G]]
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[[Category: Wang, Y]]
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[[Category: Wang Y]]
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[[Category: Xiao, J]]
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[[Category: Xiao J]]
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[[Category: Dimer]]
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[[Category: Immune system]]
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[[Category: Immunoglobulin]]
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[[Category: Secreted]]
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[[Category: Transcytosis]]
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Current revision

Cryo-EM structure of human secretory immunoglobulin A in complex with the N-terminal domain of SpsA

PDB ID 6lxw

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