6v35

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Current revision (11:19, 30 October 2024) (edit) (undo)
 
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<SX load='6v35' size='340' side='right' viewer='molstar' caption='[[6v35]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
<SX load='6v35' size='340' side='right' viewer='molstar' caption='[[6v35]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6v35]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6V35 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6V35 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6v35]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6V35 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6V35 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PGW:(1R)-2-{[(S)-{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(HEXADECANOYLOXY)METHYL]ETHYL+(9Z)-OCTADEC-9-ENOATE'>PGW</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6v22|6v22]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PGW:(1R)-2-{[(S)-{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(HEXADECANOYLOXY)METHYL]ETHYL+(9Z)-OCTADEC-9-ENOATE'>PGW</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KCNMA1, KCNMA, SLO ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), KCNMB4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6v35 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6v35 OCA], [https://pdbe.org/6v35 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6v35 RCSB], [https://www.ebi.ac.uk/pdbsum/6v35 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6v35 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6v35 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6v35 OCA], [http://pdbe.org/6v35 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6v35 RCSB], [http://www.ebi.ac.uk/pdbsum/6v35 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6v35 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/KCMB4_HUMAN KCMB4_HUMAN]] Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations.<ref>PMID:10692449</ref> <ref>PMID:10792058</ref> <ref>PMID:10828459</ref>
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[https://www.uniprot.org/uniprot/KCMA1_HUMAN KCMA1_HUMAN]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6v35" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6v35" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Potassium channel 3D structures|Potassium channel 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</SX>
</SX>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: MacKinnon, R]]
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[[Category: MacKinnon R]]
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[[Category: Tao, X]]
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[[Category: Tao X]]
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[[Category: Beta4 subunit]]
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[[Category: Bk channel]]
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[[Category: High conductance ca2+-activated k+ channel]]
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[[Category: Maxik channel]]
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[[Category: Slo1 beta subunit]]
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[[Category: Slo1 channel]]
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[[Category: Transport protein]]
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Current revision

Cryo-EM structure of Ca2+-free hsSlo1-beta4 channel complex

6v35, resolution 3.50Å

Proteopedia Page Contributors and Editors (what is this?)

OCA

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