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1u11

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[[Image:1u11.gif|left|200px]]
[[Image:1u11.gif|left|200px]]
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{{Structure
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|PDB= 1u11 |SIZE=350|CAPTION= <scene name='initialview01'>1u11</scene>, resolution 1.55&Aring;
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The line below this paragraph, containing "STRUCTURE_1u11", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= PurE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=435 Acetobacter aceti])
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|DOMAIN=
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{{STRUCTURE_1u11| PDB=1u11 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u11 OCA], [http://www.ebi.ac.uk/pdbsum/1u11 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1u11 RCSB]</span>
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}}
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'''PurE (N5-carboxyaminoimidazole Ribonucleotide Mutase) from the acidophile Acetobacter aceti'''
'''PurE (N5-carboxyaminoimidazole Ribonucleotide Mutase) from the acidophile Acetobacter aceti'''
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==About this Structure==
==About this Structure==
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1U11 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Acetobacter_aceti Acetobacter aceti]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U11 OCA].
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U11 OCA].
==Reference==
==Reference==
Acidophilic adaptations in the structure of Acetobacter aceti N5-carboxyaminoimidazole ribonucleotide mutase (PurE)., Settembre EC, Chittuluru JR, Mill CP, Kappock TJ, Ealick SE, Acta Crystallogr D Biol Crystallogr. 2004 Oct;60(Pt 10):1753-60. Epub 2004, Sep 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15388921 15388921]
Acidophilic adaptations in the structure of Acetobacter aceti N5-carboxyaminoimidazole ribonucleotide mutase (PurE)., Settembre EC, Chittuluru JR, Mill CP, Kappock TJ, Ealick SE, Acta Crystallogr D Biol Crystallogr. 2004 Oct;60(Pt 10):1753-60. Epub 2004, Sep 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15388921 15388921]
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[[Category: Acetobacter aceti]]
 
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[[Category: Protein complex]]
 
[[Category: Chittuluru, J R.]]
[[Category: Chittuluru, J R.]]
[[Category: Ealick, S E.]]
[[Category: Ealick, S E.]]
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[[Category: Mill, C P.]]
[[Category: Mill, C P.]]
[[Category: Settembre, E C.]]
[[Category: Settembre, E C.]]
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[[Category: acidophile]]
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[[Category: Acidophile]]
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[[Category: protein stability]]
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[[Category: Protein stability]]
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[[Category: pure]]
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[[Category: Pure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:37:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:03:58 2008''
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Revision as of 07:37, 3 May 2008

Image:1u11.gif

Template:STRUCTURE 1u11

PurE (N5-carboxyaminoimidazole Ribonucleotide Mutase) from the acidophile Acetobacter aceti


Overview

The crystal structure of Acetobacter aceti PurE was determined to a resolution of 1.55 A and is compared with the known structures of the class I PurEs from a mesophile, Escherichia coli, and a thermophile, Thermotoga maritima. Analyses of the general factors that increase protein stability are examined as potential explanations for the acid stability of A. aceti PurE. Increased inter-subunit hydrogen bonding and an increased number of arginine-containing salt bridges appear to account for the bulk of the increased acid stability. A chain of histidines linking two active sites is discussed in the context of the proton transfers catalyzed by the enzyme.

About this Structure

Full crystallographic information is available from OCA.

Reference

Acidophilic adaptations in the structure of Acetobacter aceti N5-carboxyaminoimidazole ribonucleotide mutase (PurE)., Settembre EC, Chittuluru JR, Mill CP, Kappock TJ, Ealick SE, Acta Crystallogr D Biol Crystallogr. 2004 Oct;60(Pt 10):1753-60. Epub 2004, Sep 23. PMID:15388921 Page seeded by OCA on Sat May 3 10:37:12 2008

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