7v3l

==MERS S ectodomain trimer in complex with neutralizing antibody 6516==

<StructureSection load='7v3l' size='340' side='right'caption='[[7v3l]], [[Resolution|resolution]] 3.47&Aring;' scene=''>

<table><tr><td colspan='2'>[[7v3l]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_betacoronavirus_2c_EMC/2012 Human betacoronavirus 2c EMC/2012]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7V3L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7V3L FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.47&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7v3l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7v3l OCA], [https://pdbe.org/7v3l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7v3l RCSB], [https://www.ebi.ac.uk/pdbsum/7v3l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7v3l ProSAT]</span></td></tr>

== Function ==

[https://www.uniprot.org/uniprot/K0BRG7_MERS K0BRG7_MERS] Spike protein S1: attaches the virion to the cell membrane by interacting with host receptor, initiating the infection.[HAMAP-Rule:MF_04099] Spike protein S2': Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099] Spike protein S2: mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099]

==See Also==

*[[Antibody 3D structures|Antibody 3D structures]]

[[Category: Homo sapiens]]

[[Category: Human betacoronavirus 2c EMC/2012]]

[[Category: Wang X]]

[[Category: Wang Z]]

[[Category: Zhao J]]